@inproceedings{IsmerRoeschKrolletal.2010, author = {Bruno Ismer and Lena R{\"o}sch and Katharina Kroll and Matthias Heinke and Thomas K{\"o}rber and Frank Weber and Ralf Peters and Christoph A. Nienaber}, title = {Left ventricular tip versus superior vena cava coil electrogram – a new approach for automatic AV delay optmization in cardiac resynchronization}, series = {Biomedical Engineering / Biomedizinische Technik}, volume = {55}, number = {S1}, publisher = {Walter de Gruyter}, address = {Berlin, Boston}, issn = {0013-5585 (Print)}, doi = {10.1515/bmt.2010.709}, pages = {9 -- 10}, year = {2010}, abstract = {AV delay (AVD) optimization can improve hemodynamics and avoid nonresponding to cardiac resynchronization therapy (CRT). AVD can be approximated by the sum of the individual implant-related interatrial conduction interval and a mean electromechanical interval of about 50ms. We searched for methods to facilitate automatic, implant-based AV delay optimization. In 25 patients (19m, 6f, age: 65±8yrs.) with Medtronic Insync III Marquis CRT-D series systems and left ventricular electrode at lateral or posterolateral wall, we determined interatrial conduction intervals by telemetric left ventricular tip versus superior vena cava coil electrogram (LVCE). Compared with esophageal measurements, the duration of optimal AV delay by LVCE showed good correlation (k=0.98, p=0.01) with a difference of 1.5±4.9ms, only. Therefore, LVCE is feasible to determine interatrial conduction intervals in order to automate AV delay optimization in CRT-D pacing promising increased accuracy compared to other algorithms.}, language = {en} }