TY - CHAP U1 - Konferenzveröffentlichung A1 - Heinke, Matthias A1 - Ismer, Bruno A1 - Kühnert, Helmut A1 - Solbrig, Olaf A1 - Surber, Ralf A1 - Haltenberger, Anna A1 - Querengässer, Jürgen A1 - Prochnau, Dirk A1 - Figulla, Hans Reiner T1 - Different impedance cardiographic parameters in atrioventricular and interventricular delay optimized biventricular pacing versus right ventricular pacing T2 - Biomedical Engineering / Biomedizinische Technik N2 - Introduction: Cardiac resynchronisation therapy (CRT) with atrioventricular (AV) and interventricular (VV) optimized biventricular pacing (BV) is an established therapy for heart failure (HF) patients. The aim of the study was to compare AV and VV delay optimization with cardiac output (CO), cardiac index (CI), contractility index (IC) and acceleration index (ACI) impedance cardiographic (ICG) methods in CRT. Methods: 15 HF patients (age 66 ± 10 years; 2 females, 13 males) in New York Heart Association (NYHA) class 3.1 ± 0.4, left ventricular (LV) ejection fraction 21.3 ± 7.8 % and QRS duration 176.1 ± 31.7 ms underwent AV and VV delay optimization with CO, CI, IC and ACI (Cardioscreen ®, Medis GmbH, Ilmenau, Germany) at different AV and VV delay BV pacing settings versus right ventricular (RV) pacing one day after implantation of a CRT device. Results: Optimal AV delay after atrial sensing was 108.6 ± 20.3 ms (n=14) and optimal AV delay after atrial pacing 190 ± 14.1 ms (n=2) with AV delay range from 80 ms to 200 ms. Optimal VV delay was -12.3 ± 25.9 ms left ventricular before RV pacing. RV versus BV pacing mode resulted in improvement of CO from 3.4 ± 1.2 l/min to 4.4 ± 1.4 l/min (p<0.001), CI from 1.8 ± 0.64 l/min/m² to 2.4 ± 0.78 l/min/m² (p<0.001), IC from 0.028 ± 0.011 1/s to 0.036 ± 0.013 1/s (p<0.001) and ACI from 0.667 ± 0.227 1/s² to 0.834 ± 0.282 1/s² (p<0.002). During 34 ± 26 month BV pacing, the NYHA class improved from 3.1 ± 0.4 to 2.1 ± 0.4 (p<0.001). Conclusion: AV and VV delay optimized BV pacing acutely improve hemodynamic parameters of transthoracic ICG and their NYHA class during long-term follow-up. ICG may be a simple and useful technique to optimize AV and VV delay in CRT. Y1 - 2011 SN - 0013-5585 (Print) SS - 0013-5585 (Print) SN - 1862-278X (Online) SS - 1862-278X (Online) U6 - https://doi.org/10.1515/bmt.2011.845 DO - https://doi.org/10.1515/bmt.2011.845 VL - 56 IS - S1 SP - 14 S1 - 1 PB - Walter de Gruyter CY - Berlin, Boston ER -