TY - JOUR U1 - Zeitschriftenartikel, wissenschaftlich - begutachtet (reviewed) A1 - Müssig, Robin A1 - Heinke, Matthias A1 - Hörth, Johannes T1 - Cryoballoon model and simulation of catheter ablation for pulmonary vein isolation in atrial fibrillation JF - Current Directions in Biomedical Engineering N2 - Pulmonary vein isolation (PVI) is a common therapy in atrial fibrillation (AF). The cryoballoon was invented to isolate the pulmonary vein in one step and in a shorter time than a point-by-point radiofrequency (RF) ablation. The aim of the study was to model two cryoballoon catheters, one RF catheter and to integrate them into a heart rhythm model for the static and dynamic simulation of PVI by cryoablation and RF ablation in AF. The modeling and simulation were carried out using the electromagnetic and thermal simulation software CST (CST, Darmstadt). Two cryoballons and one RF ablation catheter were modeled based on the technical manuals of the manufacturers Medtronic and Osypka. The PVI especially the isolation of the left inferior pulmonary vein using a cryoballoon catheter was performed with a -50 °C heatsource and an exponential signal. The temperature at the balloon surface was -50 °C after 20 s ablation time, -24 °C from the balloon 0,5 mm in the myocardium, at a distance of 1 mm -3 °C, at 2 mm 18 °C and at a distance of 3mm 29 °C. PVI with RF energy was simulated with an applied power of 5 W at 420 kHz at the distal 8 mm ablation electrode. The temperature at the tip electrode was 110 °C after 15 s ablation time, 75 °C from the balloon at 0,5 mm in the myocardium, at a distance of 1 mm 58 °C, at 2 mm 45 °C and at a distance of 3 mm 38 °C. Virtual heart rhythm and catheter models as well as the simulation of the temperature allow the simulation of PVI in AF by cryo ablation and RF ablation. The 3D simulation of the temperature profile may be used to optimize RF and cryo ablation. KW - pulmonary vein isolation KW - atrial fibrillation KW - radiofrequency ablation KW - cryo ablation KW - cryoballoon Y1 - 2018 UR - https://www.degruyter.com/view/j/cdbme.2018.4.issue-1/cdbme-2018-0113/cdbme-2018-0113.xml?format=INT SN - 2364-5504 SS - 2364-5504 U6 - https://doi.org/10.1515/cdbme-2018-0113 DO - https://doi.org/10.1515/cdbme-2018-0113 VL - 4 IS - 1 SP - 473 EP - 475 PB - De Gruyter CY - Berlin ER -