TY - CHAP U1 - Konferenzveröffentlichung A1 - Haltenberger, Anna A1 - Eisenträger, Daniela A1 - Ismer, Bruno A1 - Solbrig, Olaf A1 - Querengässer, Jürgen A1 - Winkler, Andreas A1 - Allmann, Jakob A1 - Töpfer, Anja A1 - Figulla, Hans Reiner A1 - Heinke, Matthias T1 - Analysing-software for impedance and electrocardiography – what is currently possible? T2 - Biomedical Engineering / Biomedizinische Technik N2 - Introduction: Cardiac resynchronization therapy (CRT) with biventricular (BV) pacing is an established therapy for heart failure (HF) patients with ventricular desynchronisation and reduced left ventricular (LV) function. The aim of this study was to evaluate preejection period (PEP) and left ventricular ejection time (LVET) with transthoracic signal averaging impedance and electrocardiography in HF patients with and without BV pacing. Methods: 10 HF patients (age 68.9 ± 8 years; 2 females, 9 males) with New York Heart Association (NYHA) class 2,9 ± 0.5, 30.9 ± 10.5 % LV ejection fraction and 159.4 ± 22.9 ms QRS duration were analysed with transthoracic impedance and electrocardiography (Cardioscreen Medis, Ilmenau, Germany) and novel National Intruments LabView 2009 signal averaging software. One day after BV pacing device implantation, AV and VV delays were optimized by transthoracic impedance cardiography and stroke volume (SV) and cardiac output (CO) were gained by Cardioscreen. Results: Transthoracic impedance and electrocardiography AV and VV delay opimization was possible in all HF patients with BV pacing devices (n= 10). PEP was 154 ± 24ms without BV pacing and measured between onset of QRS in the surface electrocardiogram and onset of ventricular deflection in the impedance cardiogram. LVET was 342 ± 65ms without BV pacing and measured between onset and offset of ventricular deflection in the impedance cardiogram. The use of optimal AV and VV delay BV pacing resulted in improvement of SV from 64.1 ± 26.5 ml to 94.1 ± 33.96 ml (P < 0.05) and CO from 4.05 ± 1.36 l/min to 6.44 ± 1.56 l/min (P < 0.05). Conclusion: PEP and LVET may be useful parameters of ventricular Desynchronisation. AV and VV delay optimized BV pacing improve SV and CO. Impedance and electrocardiography with LabView 2009 signal averaging may be a simple and useful technique to optimize CRT. Y1 - 2011 SN - 0013-5585 (Print) SS - 0013-5585 (Print) SN - 1862-278X (Online) SS - 1862-278X (Online) U6 - https://doi.org/10.1515/bmt.2011.856 DO - https://doi.org/10.1515/bmt.2011.856 IS - S1 SP - 8 S1 - 1 PB - Walter de Gruyter CY - Berlin, Boston ET - 56 ER -