TY - JOUR U1 - Zeitschriftenartikel, wissenschaftlich - begutachtet (reviewed) A1 - Roller, Tom A1 - Heinke, Matthias A1 - Hörth, Johannes T1 - Pacing electrode modeling and simulation of cardiac contractility modulation JF - Current Directions in Biomedical Engineering N2 - Cardiac contractility modulation (CCM) is a device-based therapy for the treatment of systolic left ventricular chronic heart failure. Unlike other device-based therapies for heart failure, CCM delivers non-excitatory pacing signals to the myocardium. This leads to an extension of the action potential and to an improved contractility of the heart. The modeling and simulation was done with the electromagnetic simulation software CST. Three CCM electrodes were inserted into the Offenburg heart rhythm model and subsequently simulated the electric field propagation in CCM therapy. In addition, simulations of CCM have been performed with electrodes from other device-based therapies, such as cardiac resynchronization therapy (CRT) and implantable cardioverter / defibrillator (ICD) therapy. At the same distance to the simulation electrode, the electric field is slightly stronger in CCM therapy than in CCM therapy with additionally implanted CRT or ICD electrodes. In addition, there is a change in the electric field propagation at the electrodes of the CRT and the shock electrode of the ICD. By simulating several different therapy procedures on the heart, it is possible to check how they affect their behavior during normal operation. CCM heart rhythm model simulation allows the evaluation the individual electrical pacing and sensing field during CCM. KW - cardiac contractility modulation KW - cardiac resynchronization therapy KW - heart failure KW - heart rhythm simulation KW - heart rhythm model Y1 - 2018 UR - https://www.degruyter.com/view/j/cdbme.2018.4.issue-1/cdbme-2018-1131/cdbme-2018-1131.xml?format=INT SN - 2364-5504 SS - 2364-5504 U6 - https://doi.org/10.1515/cdbme-2018-1131 DO - https://doi.org/10.1515/cdbme-2018-1131 VL - 4 IS - 1 SP - 551 EP - 554 PB - De Gruyter CY - Berlin ER -