@incollection{GlaudemansDierckxOtteetal., author = {Glaudemans, Andor W. J. M. and Dierckx, Rudi A. J. O. and Otte, Andreas and Pruim, Jan}, title = {Good Clinical Practice and Nuclear Medicine}, series = {Trends on the role of PET in drug development}, editor = {Elsinga, Philip H.}, publisher = {World Scientific Publishing Co. Pte. Ltd.}, address = {Singapore}, isbn = {978-981-4317-73-3}, pages = {691 -- 726}, language = {en} } @incollection{vanRheenenStroomezandvanAmerongenetal., author = {van Rheenen, Ronald W. J. and Stroomezand, Gilles N. and van Amerongen, Jacoba P. and Otte, Andreas and De Deyn, Peter Paul and Dierckx, Rudi A. J. O.}, title = {Perfusion SPECT: Its Role in the Diagnosis and Differential Diagnosis of Alzheimer's Disease, with Particular Emphasis on Guidelines}, series = {PET and SPECT in Neurology}, editor = {Dierckx, Rudi A. J. O. and Otte, Andreas and de Vries, Erik F. J. and van Waarde, Aren and Leenders, Klaus L.}, edition = {2.}, publisher = {Springer International Publishing}, address = {Cham, Schweiz}, isbn = {978-3-030-53167-6 (Hardcover)}, doi = {10.1007/978-3-030-53168-3_14}, pages = {453 -- 468}, abstract = {Dementia is a clinical diagnosis reflecting many possible underlying pathologies, for example, vascular dementia and neurodegenerative disorders such as frontotemporal dementia, Lewy body-type disorder or Alzheimer's disease (AD). The breakthrough of 99mtechnetium-labelled perfusion tracers in the 1990s resulted in many SPECT studies of flow changes in AD. In the first decade of 2000, the role of perfusion SPECT was shifted from diagnosis towards differential diagnosis, parallel to the growing attention for diagnosing early stages of dementia. Previously a diagnosis based largely on a process of exclusion, new guidelines have emerged increasingly employing positive criteria to establish the diagnosis, including neuroimaging biomarkers. Nowadays, FDG PET has largely limited the role of perfusion SPECT, although it is still considered a valuable and cost-effective alternative when PET is not available.}, language = {en} } @incollection{DierckxOttedeVriesetal., author = {Dierckx, Rudi A. J. O. and Otte, Andreas and de Vries, Erik F. J. and van Waarde, Aren}, title = {Preface}, series = {PET and SPECT of Neurobiological Systems}, editor = {Dierckx, Rudi A. J. O. and Otte, Andreas and de Vries, Erik F. J. and van Waarde, Aren and Lammertsma, Adriaan A.}, publisher = {Springer International Publishing}, address = {Cham}, isbn = {978-3-030-53175-1}, doi = {10.1007/978-3-030-53176-8}, pages = {vii -- viii}, language = {en} } @article{OtteDierckxHolstegeetal., author = {Otte, Andreas and Dierckx, Rudi A. J. O. and Holstege, Gert and V{\´a}llez Garcia, David}, title = {Chronic whiplash-associated disorders}, series = {Lancet, The}, volume = {384}, number = {9951/2014}, issn = {0140-6736}, doi = {10.1016/S0140-6736(14)61814-6}, pages = {1346 -- 1346}, language = {en} } @article{VallezGarciaOtteDierckxetal., author = {V{\´a}llez Garcia, David and Otte, Andreas and Dierckx, Rudi A. J. O. and Doorduin, Janine}, title = {Three Month Follow-Up of Rat Mild Traumatic Brain Injury}, series = {Journal of Neurotrauma}, volume = {33}, number = {20}, doi = {10.1089/neu.2015.4230}, pages = {1855 -- 1865}, language = {en} } @article{VallezGarciaDoorduinWillemsenetal., author = {V{\´a}llez Garcia, David and Doorduin, Janine and Willemsen, Antoon T. M. and Dierckx, Rudi A. J. O. and Otte, Andreas}, title = {Altered Regional Cerebral Blood Flow in Chronic Whiplash Associated Disorders}, series = {EBioMedicine}, volume = {10}, number = {8/2016}, issn = {2352-3964}, doi = {10.1016/j.ebiom.2016.07.008}, pages = {249 -- 257}, abstract = {There is increasing evidence of central hyperexcitability in chronic whiplash-associated disorders (cWAD). However, little is known about how an apparently simple cervical spine injury can induce changes in cerebral processes. The present study was designed (1) to validate previous results showing alterations of regional cerebral blood flow (rCBF) in cWAD, (2) to test if central hyperexcitability reflects changes in rCBF upon non-painful stimulation of the neck, and (3) to verify our hypothesis that the missing link in understanding the underlying pathophysiology could be the close interaction between the neck and midbrain structures. For this purpose, alterations of rCBF were explored in a case-control study using H215O positron emission tomography, where each group was exposed to four different conditions, including rest and different levels of non-painful electrical stimulation of the neck. rCBF was found to be elevated in patients with cWAD in the posterior cingulate and precuneus, and decreased in the superior temporal, parahippocampal, and inferior frontal gyri, the thalamus and the insular cortex when compared with rCBF in healthy controls. No differences in rCBF were observed between different levels of electrical stimulation. The alterations in regions directly involved with pain perception and interoceptive processing indicate that cWAD symptoms might be the consequence of a mismatch during the integration of information in brain regions involved in pain processing.}, language = {en} } @inproceedings{VallezGarciaOtteWillemsenetal., author = {V{\´a}llez Garcia, David and Otte, Andreas and Willemsen, Antoon T. M. and Dierckx, Rudi A. J. O. and Doorduin, Janine and Hostege, Gert}, title = {Altered Regional Cerebral Blood Flow in Chronic Whiplash Associated Disorder}, series = {European Journal of Nuclear Medicine and Molecular Imaging}, volume = {42}, number = {Suppl. 1}, publisher = {Springer}, address = {Berlin, Heidelberg}, organization = {European Association of Nuclear Medicine}, issn = {1619-7070}, doi = {10.1007/s00259-015-3198-z}, pages = {S215 -- S216}, language = {en} } @inproceedings{VallezGarciaOtteDierckxetal., author = {Vallez Garcia, David and Otte, Andreas and Dierckx, Rudi A. J. O. and Doorduin, Janine}, title = {Three months follow-up of mild traumatic brain injury in rats: a combined [18F]FDG and [11C]PK11195 PET study}, series = {Annual Congressof the European Association of Nuclear Medicine October 10 - 14, 2015 Hamburg, Germany European Journal of Nuclear Medicine and Molecular Imaging}, volume = {42}, number = {Supplement 1}, publisher = {Springer}, address = {Berlin, Heidelberg}, issn = {1619-7089}, doi = {10.1007/s00259-015-3198-z}, pages = {583 -- 584}, language = {en} }