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Perfusion SPECT: Its Role in the Diagnosis and Differential Diagnosis of Alzheimer's Disease, with Particular Emphasis on Guidelines

  • Dementia is a clinical diagnosis reflecting many possible underlying pathologies, for example, vascular dementia and neurodegenerative disorders such as frontotemporal dementia, Lewy body-type disorder or Alzheimer’s disease (AD). The breakthrough of 99mtechnetium-labelled perfusion tracers in the 1990s resulted in many SPECT studies of flow changes in AD. In the first decade of 2000, the role ofDementia is a clinical diagnosis reflecting many possible underlying pathologies, for example, vascular dementia and neurodegenerative disorders such as frontotemporal dementia, Lewy body-type disorder or Alzheimer’s disease (AD). The breakthrough of 99mtechnetium-labelled perfusion tracers in the 1990s resulted in many SPECT studies of flow changes in AD. In the first decade of 2000, the role of perfusion SPECT was shifted from diagnosis towards differential diagnosis, parallel to the growing attention for diagnosing early stages of dementia. Previously a diagnosis based largely on a process of exclusion, new guidelines have emerged increasingly employing positive criteria to establish the diagnosis, including neuroimaging biomarkers. Nowadays, FDG PET has largely limited the role of perfusion SPECT, although it is still considered a valuable and cost-effective alternative when PET is not available.show moreshow less

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Author:Ronald W. J. van Rheenen, Gilles N. Stroomezand, Jacoba P. van Amerongen, Andreas OtteORCiDGND, Peter Paul De Deyn, Rudi A. J. O. Dierckx
Editor:Rudi A. J. O. Dierckx, Andreas Otte, Erik F. J. de Vries, Aren van Waarde, Klaus L. Leenders
Publisher:Springer International Publishing
Place of publication:Cham, Schweiz
Year of Publication:2021
Date of first Publication:2020/10/21
Edition:2.
ISBN:978-3-030-53167-6 (Hardcover)
ISBN:978-3-030-53168-3 (eBook)
Language:English
DDC classes:600 Technik, Medizin, angewandte Wissenschaften
Parent Title (English):PET and SPECT in Neurology
First Page:453
Last Page:468
Document Type:Part of a Book
Institutes:Bibliografie
Acces Right:Zugriffsbeschränkt
Release Date:2020/10/22
Licence (German):License LogoEs gilt das UrhG
DOI:https://doi.org/10.1007/978-3-030-53168-3_14