Molybdenum as a Potential Biocompatible and Resorbable Material for Osteosynthesis in Craniomaxillofacial Surgery—An In Vitro Study
- Titanium and stainless steel are commonly known as osteosynthesis materials with high strength and good biocompatibility. However, they have the big disadvantage that a second operation for hardware removal is necessary. Although resorbable systems made of polymers or magnesium are increasingly used, they show some severe adverse foreign body reactions or unsatisfying degradation behavior.Titanium and stainless steel are commonly known as osteosynthesis materials with high strength and good biocompatibility. However, they have the big disadvantage that a second operation for hardware removal is necessary. Although resorbable systems made of polymers or magnesium are increasingly used, they show some severe adverse foreign body reactions or unsatisfying degradation behavior. Therefore, we started to investigate molybdenum as a potential new biodegradable material for osteosynthesis in craniomaxillofacial surgery. To characterize molybdenum as a biocompatible material, we performed in vitro assays in accordance with ISO Norm 10993-5. In four different experimental setups, we showed that pure molybdenum and molybdenum rhenium alloys do not lead to cytotoxicity in human and mouse fibroblasts. We also examined the degradation behavior of molybdenum by carrying out long-term immersion tests (up to 6 months) with molybdenum sheet metal. We showed that molybdenum has sufficient mechanical stability over at least 6 months for implants on the one hand and is subject to very uniform degradation on the other. The results of our experiments are very promising for the development of new resorbable osteosynthesis materials for craniomaxillofacial surgery based on molybdenum.…
Document Type: | Article (reviewed) |
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Zitierlink: | https://opus.hs-offenburg.de/6642 | Bibliografische Angaben |
Title (English): | Molybdenum as a Potential Biocompatible and Resorbable Material for Osteosynthesis in Craniomaxillofacial Surgery—An In Vitro Study |
Author: | André Toschka, Georg Pöhle, Peter QuadbeckStaff MemberORCiDGND, Christoph Suschek, Alexander Strauß, Christian Redlich, Majeed Rana |
Year of Publication: | 2022 |
Date of first Publication: | 2022/12/11 |
Place of publication: | Basel |
Publisher: | MDPI |
First Page: | 1 |
Last Page: | 15 |
Article Number: | 15710 |
Parent Title (English): | International Journal of Molecular Sciences |
Volume: | 23 |
Issue: | 24 |
ISSN: | 1422-0067 (Online) |
ISSN: | 1661-6596 (Print) |
DOI: | https://doi.org/10.3390/ijms232415710 |
URN: | https://urn:nbn:de:bsz:ofb1-opus4-66420 |
Language: | English | Inhaltliche Informationen |
Institutes: | Fakultät Elektrotechnik, Medizintechnik und Informatik (EMI) (ab 04/2019) |
Forschung / POIM - Peter Osypka Institute of Medical Engineering | |
Collections of the Offenburg University: | Bibliografie |
DDC classes: | 600 Technik, Medizin, angewandte Wissenschaften |
Tag: | biodegradable implants; biomaterials; craniomaxillofacial surgery; molybdenum; osteosynthesis |
Funded by (selection): | Bundesministerium für Bildung und Forschung | Formale Angaben |
Relevance for "Jahresbericht über Forschungsleistungen": | Wiss. Zeitschriftenartikel reviewed: Listung in AG IV-Liste |
Open Access: | Open Access |
Gold | |
Licence (German): | Creative Commons - CC BY - Namensnennung 4.0 International |