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Molybdenum as a Potential Biocompatible and Resorbable Material for Osteosynthesis in Craniomaxillofacial Surgery—An In Vitro Study

  • Titanium and stainless steel are commonly known as osteosynthesis materials with high strength and good biocompatibility. However, they have the big disadvantage that a second operation for hardware removal is necessary. Although resorbable systems made of polymers or magnesium are increasingly used, they show some severe adverse foreign body reactions or unsatisfying degradation behavior.Titanium and stainless steel are commonly known as osteosynthesis materials with high strength and good biocompatibility. However, they have the big disadvantage that a second operation for hardware removal is necessary. Although resorbable systems made of polymers or magnesium are increasingly used, they show some severe adverse foreign body reactions or unsatisfying degradation behavior. Therefore, we started to investigate molybdenum as a potential new biodegradable material for osteosynthesis in craniomaxillofacial surgery. To characterize molybdenum as a biocompatible material, we performed in vitro assays in accordance with ISO Norm 10993-5. In four different experimental setups, we showed that pure molybdenum and molybdenum rhenium alloys do not lead to cytotoxicity in human and mouse fibroblasts. We also examined the degradation behavior of molybdenum by carrying out long-term immersion tests (up to 6 months) with molybdenum sheet metal. We showed that molybdenum has sufficient mechanical stability over at least 6 months for implants on the one hand and is subject to very uniform degradation on the other. The results of our experiments are very promising for the development of new resorbable osteosynthesis materials for craniomaxillofacial surgery based on molybdenum.show moreshow less

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Metadaten
Document Type:Article (reviewed)
Zitierlink: https://opus.hs-offenburg.de/6642
Bibliografische Angaben
Title (English):Molybdenum as a Potential Biocompatible and Resorbable Material for Osteosynthesis in Craniomaxillofacial Surgery—An In Vitro Study
Author:André Toschka, Georg Pöhle, Peter QuadbeckStaff MemberORCiDGND, Christoph Suschek, Alexander Strauß, Christian Redlich, Majeed Rana
Year of Publication:2022
Date of first Publication:2022/12/11
Place of publication:Basel
Publisher:MDPI
First Page:1
Last Page:15
Article Number:15710
Parent Title (English):International Journal of Molecular Sciences
Volume:23
Issue:24
ISSN:1422-0067 (Online)
ISSN:1661-6596 (Print)
DOI:https://doi.org/10.3390/ijms232415710
URN:https://urn:nbn:de:bsz:ofb1-opus4-66420
Language:English
Inhaltliche Informationen
Institutes:Fakultät Elektrotechnik, Medizintechnik und Informatik (EMI) (ab 04/2019)
Forschung / POIM - Peter Osypka Institute of Medical Engineering
Collections of the Offenburg University:Bibliografie
DDC classes:600 Technik, Medizin, angewandte Wissenschaften
Tag:biodegradable implants; biomaterials; craniomaxillofacial surgery; molybdenum; osteosynthesis
Funded by (selection):Bundesministerium für Bildung und Forschung
Formale Angaben
Relevance for "Jahresbericht über Forschungsleistungen":Wiss. Zeitschriftenartikel reviewed: Listung in AG IV-Liste
Open Access: Open Access 
 Gold 
Licence (German):License LogoCreative Commons - CC BY - Namensnennung 4.0 International