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Pacing electrode modeling and simulation of cardiac contractility modulation

  • Cardiac contractility modulation (CCM) is a device- based therapy for the treatment of systolic left ventricular chronic heart failure. Unlike other device - based therapies for heart failure, CCM delivers non - excitatory pacing signals to the myocardium. This leads to an extension of the action potential and to an improved contractility of theCardiac contractility modulation (CCM) is a device- based therapy for the treatment of systolic left ventricular chronic heart failure. Unlike other device - based therapies for heart failure, CCM delivers non - excitatory pacing signals to the myocardium. This leads to an extension of the action potential and to an improved contractility of the heart. The modeling and simulation was done with the electromagnetic simulation software CST. Three CCM electrodes were inserted into the Offenburg heart rhythm model an d subsequently simulated the electric field propagation in CCM therapy. In addition, simulations of CCM have been performed with electrodes from other device -based therapies, such as cardiac resynchronization therapy (CRT) and implantable cardioverter. /. defi brillator (ICD) therapy. At the same distance to the simulation electrode, the electric field is slightly stronger in CCM therapy than in CCM therapy with additionally implanted CRT or ICD electrodes. In addition, there is a change in the electric field pr opagation at the electrodes of the CRT and the shock electrode of the ICD. By simulating several different therapy procedures on the heart, it is possible to check how they affect their behavior during normal operation. CCM heart rhythm model simulation al lows the evaluation the individual electrical pacing and sensing field during CCM.show moreshow less

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Metadaten
Author:Tom Roller, Matthias Heinke, Johannes Hörth
Publisher:De Gruyter
Place of publication:Berlin
Year of Publication:2018
Language:English
GND Keyword:cardiac contractility modulation; cardiac resynchronization therapy; heart failure; heart rhythm model; heart rhythm simulation
Tag:cardiac contractility modulation; cardiac resynchronization therapy; heart failure; heart rhythm model; heart rhythm simulation
DDC classes:600 Technik, Medizin, angewandte Wissenschaften
Parent Title (English):Current Directions in Biomedical Engineering
Volume:4
Issue:1
ISSN:2364-5504
First Page:551
Last Page:554
Document Type:Article (reviewed)
Institutes:Hochschule Offenburg / Bibliografie
Acces Right:Frei zugänglich
Release Date:2018/12/05
Licence (German):License LogoEs gilt das UrhG
URL:https://www.degruyter.com/view/j/cdbme.2018.4.issue-1/cdbme-2018-1131/cdbme-2018-1131.xml?format=INT
DOI:https://doi.org/10.1515/cdbme-2018-1131