Volltext-Downloads (blau) und Frontdoor-Views (grau)
  • search hit 22 of 3334
Back to Result List

Advanced fibre optical scanning in thin-layer chromatography for drug identification

  • A systematic toxicological analysis procedure using high-performance thin layer chromatography in combination with fibre optical scanning densitometry for identification of drugs in biological samples is presented. Two examples illustrate the practicability of the technique. First, the identification of a multiple intake of analgesics: codeine, propyphenazone, tramadol, flupirtine and lidocaine,A systematic toxicological analysis procedure using high-performance thin layer chromatography in combination with fibre optical scanning densitometry for identification of drugs in biological samples is presented. Two examples illustrate the practicability of the technique. First, the identification of a multiple intake of analgesics: codeine, propyphenazone, tramadol, flupirtine and lidocaine, and second, the detection of the sedative diphenhydramine. In both cases, authentic urine specimens were used. The identifications were carried out by an automatic measurement and computer-based comparison of in situ UV spectra with data from a compiled library of reference spectra using the cross-correlation function. The technique allowed a parallel recording of chromatograms and in situ UV spectra in the range of 197–612 nm. Unlike the conventional densitometry, a dependency of UV spectra by concentration of substance in a range of 250–1000 ng/spot was not observed.show moreshow less

Export metadata

Additional Services

Search Google Scholar

Statistics

frontdoor_oas
Metadaten
Document Type:Article (reviewed)
Zitierlink: https://opus.hs-offenburg.de/3482
Bibliografische Angaben
Title (English):Advanced fibre optical scanning in thin-layer chromatography for drug identification
Author:Björn Ahrens, Dirk Blankenhorn, Bernd SpangenbergStaff MemberORCiDGND
Year of Publication:2002
Publisher:Elsevier
First Page:11
Last Page:18
Parent Title (English):Journal of Chromatography B
Volume:772
Issue:1
ISSN:1873-376X
DOI:https://doi.org/10.1016/S1570-0232(01)00617-1
Language:English
Inhaltliche Informationen
Institutes:Fakultät Maschinenbau und Verfahrenstechnik (M+V)
Institutes:Bibliografie
GND Keyword:Dichtebestimmung; Dünnschichtchromatographie; Faseroptik
Formale Angaben
Open Access: Closed Access 
Licence (German):License LogoUrheberrechtlich geschützt