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Numerical analysis of the diffusive mass transport in brain tissues with applications to optical sensors

  • In the brain-cell microenvironment, diffusion plays an important role: apart from delivering glucose and oxygen from the vascular system to brain cells, it also moves informational substances between cells. The brain is an extremely complex structure of interwoven, intercommunicating cells, but recent theoretical and experimental works showed that the classical laws of diffusion, cast in theIn the brain-cell microenvironment, diffusion plays an important role: apart from delivering glucose and oxygen from the vascular system to brain cells, it also moves informational substances between cells. The brain is an extremely complex structure of interwoven, intercommunicating cells, but recent theoretical and experimental works showed that the classical laws of diffusion, cast in the framework of porous media theory, can deliver an accurate quantitative description of the way molecules are transported through this tissue. The mathematical modeling and the numerical simulations are successfully applied in the investigation of diffusion processes in tissues, replacing the costly laboratory investigations. Nevertheless, modeling must rely on highly accurate information regarding the main parameters (tortuosity, volume fraction) which characterize the tissue, obtained by structural and functional imaging. The usual techniques to measure the diffusion mechanism in brain tissue are the radiotracer method, the real time iontophoretic method and integrative optical imaging using fluorescence microscopy. A promising technique for obtaining the values for characteristic parameters of the transport equation is the direct optical investigation using optical fibers. The analysis of these parameters also reveals how the local geometry of the brain changes with time or under pathological conditions. This paper presents a set of computations concerning the mass transport inside the brain tissue, for different types of cells. By measuring the time evolution of the concentration profile of an injected substance and using suitable fitting procedures, the main parameters characterizing the tissue can be determined. This type of analysis could be an important tool in understanding the functional mechanisms of effective drug delivery in complex structures such as the brain tissue. It also offers possibilities to realize optical imaging methods for in vitro and in vivo measurements using optical fibers. The model also may help in radiotracer biomarker models for the understanding of the mechanism of action of new chemical entities.show moreshow less

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Metadaten
Document Type:Conference Proceeding
Conference Type:Konferenzartikel
Zitierlink: https://opus.hs-offenburg.de/687
Bibliografische Angaben
Title (English):Numerical analysis of the diffusive mass transport in brain tissues with applications to optical sensors
Conference:SPIE BiOS. Optical fibers and sensors for medical diagnostics and treatment applications XIII, 2-3 Februar 2013, San Francisco, California, United States
Author:Dan CurticapeanStaff MemberGND, Andreas OtteStaff MemberORCiDGND, Adrian Neculae
Date of Publication (online):2013/03/20
Creating Corporation:Society of Photo-Optical Instrumentation Engineers
Place of publication:Bellingham, Washington
Publisher:SPIE
First Page:857605-1
Last Page:857605-9
Article Number:857605
Parent Title (English):Proceedings of SPIE: Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XIII
Editor:Israel Gannot
Volume:8576
ISSN:0277-786X
DOI:https://doi.org/10.1117/12.2004436
Language:English
Inhaltliche Informationen
Institutes:Forschung / IUAS - Institute for Unmanned Aerial Systems
Fakultät Elektrotechnik und Informationstechnik (E+I) (bis 03/2019)
Fakultät Medien und Informationswesen (M+I) (bis 21.04.2021)
Institutes:Bibliografie
Tag:Gehirn; Gewebe; Optik; Sensortechnik
Formale Angaben
Open Access: Closed Access 
Licence (German):License LogoUrheberrechtlich geschützt