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Deep generative models have recently achieved impressive results for many real-world applications, successfully generating high-resolution and diverse samples from complex datasets. Due to this improvement, fake digital contents have proliferated growing concern and spreading distrust in image content, leading to an urgent need for automated ways to detect these AI-generated fake images.
Despite the fact that many face editing algorithms seem to produce realistic human faces, upon closer examination, they do exhibit artifacts in certain domains which are often hidden to the naked eye. In this work, we present a simple way to detect such fake face images - so-called DeepFakes. Our method is based on a classical frequency domain analysis followed by basic classifier. Compared to previous systems, which need to be fed with large amounts of labeled data, our approach showed very good results using only a few annotated training samples and even achieved good accuracies in fully unsupervised scenarios. For the evaluation on high resolution face images, we combined several public datasets of real and fake faces into a new benchmark: Faces-HQ. Given such high-resolution images, our approach reaches a perfect classification accuracy of 100% when it is trained on as little as 20 annotated samples. In a second experiment, in the evaluation of the medium-resolution images of the CelebA dataset, our method achieves 100% accuracy supervised and 96% in an unsupervised setting. Finally, evaluating a low-resolution video sequences of the FaceForensics++ dataset, our method achieves 91% accuracy detecting manipulated videos.
Recent deep learning based approaches have shown remarkable success on object segmentation tasks. However, there is still room for further improvement. Inspired by generative adversarial networks, we present a generic end-to-end adversarial approach, which can be combined with a wide range of existing semantic segmentation networks to improve their segmentation performance. The key element of our method is to replace the commonly used binary adversarial loss with a high resolution pixel-wise loss. In addition, we train our generator employing stochastic weight averaging fashion, which further enhances the predicted output label maps leading to state-of-the-art results. We show, that this combination of pixel-wise adversarial training and weight averaging leads to significant and consistent gains in segmentation performance, compared to the baseline models.
Recent studies have shown remarkable success in image-to-image translation for attribute transfer applications. However, most of existing approaches are based on deep learning and require an abundant amount of labeled data to produce good results, therefore limiting their applicability. In the same vein, recent advances in meta-learning have led to successful implementations with limited available data, allowing so-called few-shot learning.
In this paper, we address this limitation of supervised methods, by proposing a novel approach based on GANs. These are trained in a meta-training manner, which allows them to perform image-to-image translations using just a few labeled samples from a new target class. This work empirically demonstrates the potential of training a GAN for few shot image-to-image translation on hair color attribute synthesis tasks, opening the door to further research on generative transfer learning.
In this preliminary report, we present a simple but very effective technique to stabilize the training of CNN based GANs. Motivated by recently published methods using frequency decomposition of convolutions (e.g. Octave Convolutions), we propose a novel convolution scheme to stabilize the training and reduce the likelihood of a mode collapse. The basic idea of our approach is to split convolutional filters into additive high and low frequency parts, while shifting weight updates from low to high during the training. Intuitively, this method forces GANs to learn low frequency coarse image structures before descending into fine (high frequency) details. Our approach is orthogonal and complementary to existing stabilization methods and can simply plugged into any CNN based GAN architecture. First experiments on the CelebA dataset show the effectiveness of the proposed method.
Die Katheterablation mit Hochfrequenzstrom (HF) ist der Goldstandard für die Therapie vieler kardi-aler Tachyarrhythmien. Bei der HF-Ablation entstehen Temperaturen zwischen 50 °C und 70 °C, wo-durch bestimmte Strukturen im Herzgewebe gezielt zerstört werden können. Ziel der Studie ist, die HF-Ablation und deren Wärmeausbreitung in Bezug auf die zugeführte Leistung mit unterschiedli-chem Elektrodenmaterial und Elektrodengröße bei supraventrikülären Tachykardien zu simulieren.
Background: The application of high-frequency ablation is used for the treatment of tachycardia arrhythmias and is a respected method. Ablation with high frequency current leads to the targeted heat destruction of myocardial tissue at specific sites and thus prevents the pathological propagation of excitation through these structures.
Purpose: The aim of this study was to simulate heat propagation during RF ablation with modeled electrodes in different sizes and materials. The simulation was performed on atrioventricular node re-entry tachycardia (AVNRT), atrioventricular re-entry tachycardia (AVRT) and atrial flutter (AFL).
Methods: Using the modeling and simulation software CST, ablation catheters with 4 mm and 8 mm tip electrodes were modeled from gold and platinum for each. The designed catheters correspond to the manufacturer"s specifications of Medtronic, Biotronik and Osypka. The catheters were integrated into the Offenburg heart rhythm model to simulate and compare the heat propagation during an ablation application, which also takes into account the blood flow in the four heart chambers. A power of 5 W - 40 W was simulated for the 4 mm electrodes and a power of 50 W - 80 W for the 8 mm electrodes.
Results: During the simulated HF ablation application, the temperature at the ablation electrode was measured at different powers. This is 40.67°C at 5 W, 44.34°C at 10 W, 51.76°C at 20 W, 59.0°C at 30 W, and 66.33°C at 40 W. The measured temperature during 40 W application is 39.5°C at 0,5 mm depth in the myocardium and 37.5°C at 2 mm depth.
In the simulation, the 8 mm platinum electrode reached an ablation temperature of 72.85°C at its tip during an applied power of 60 W. In contrast, the 8 mm platinum electrode reached a depth of 5 mm at 39.5 C° and at a depth of 2 mm at 37.5 °C. In contrast, the 8 mm gold electrode reached a temperature of 64.66°C with the same performance. This is due to the thermal properties of gold, which has a better thermal conductivity than platinum.
Conclusions: CST offers the possibility to carry out a static and dynamic simulation of a heart model and the ablation electrodes integrated in it during an HF ablation. In variation with different electrode sizes and materials, therapy methods for the treatment of AVNRT, AVRT and AFL can be optimized
We present a planar chromatographic separation method for the compounds caffeine, artemisinin, and equol, separated on high-performance thin-layer chromatography (HPTLC) silica gel plates. As solvents for separation, methyl t-butyl ether and cyclohexane (1:1, V/V) have been used for equol, cyclohexane and ethyl acetate (7:3, V/V) for artemisinin, and ethyl acetate and acetone (7:3, V/V) for caffeine. After separation, the plate was scanned with a very specific time of flight-direct analysis in real time-mass spectrometry (TOF-DART-MS) system using the (M + 1)+ signals of equol, artemisinin, and caffeine. The (M + 1) peak of artemisinin at 283.13 m/z is clearly detectable, which is the proof that DART-MS is applicable for the quantitative determination of rather instable molecules. The planar set-up of DART source, HPTLC plate and detector inlet in a line showed higher sensitivities compared to desorption at an angle. The optimal detector voltage increases with the molar mass of the analyte, thus an individual determination of optimal detector voltage setting for the different analyte is recommended to achieve the best possible measurement conditions. In conclusion, DART-MS detection in combination with an HPTLC separation allows very specific quantification of all three compounds.
Narrowband IoT (NB-IoT) as a radio access technology for the cellular Internet of Things (cIoT) is getting more traction due to attractive system parameters, new proposals in the 3 rd Generation Partnership Project (3GPP) Release 14 for reduced power consumption and ongoing world-wide deployment. As per 3GPP, the low-power and wide-area use cases in 5G specification will be addressed by the early NB-IoT and Long-Term Evolution for Machines (LTE-M) based technologies. Since these cIoT networks will operate in a spatially distributed environment, there are various challenges to be addressed for tests and measurements of these networks. To meet these requirements, unified emulated and field testbeds for NB-IoT-networks were developed and used for extensive performance measurements. This paper analyses the results of these measurements with regard to RF coverage, signal quality, latency, and protocol consistency.
Es ist schon beeindruckend, welche Fähigkeiten die Menschen den Computern mittlerweile geben konnten. Dennoch muss man nicht der Maschinenstürmerei (Luddismus) zuneigen, um durch das zuweilen überbordende Maß an Optimismus irritiert zu sein, das den Fähigkeiten von Algorithmen und künstlicher Intelligenz zuweilen zugeschrieben wird. Nahezu alle Wirtschaftsbereiche sollen durch sie alsbald „revolutioniert“ werden, "disruptive Veränderungen" werden prognostiziert. Politiker fordern und Max-Planck-Forscher kündigen jetzt die Entwicklung von „fairen“ Algorithmen an. Einige kritische Anmerkungen erscheinen angezeigt, denn fair kann ein Algorithmus nicht sein.
Das Geschäftsgeheimnisgesetz - Praxisrelevante Aspekte der Umsetzung der EU Richtlinie 2016/943
(2019)
Geschäftsgeheimnisse sind wertvoll. Mit dem neuen Geschäftsgeheimnisgesetz vom 18.4.2019 (Gesetz zum Schutz von Geschäftsgeheimnissen – GeschGehG, BGBl. I 2019, 466) ist die Know-how-Richtlinie (Richtlinie (EU) 2016/943 des Europäischen Parlaments und des Rates vom 8.6.2016 über den Schutz vertraulichen Know-hows und vertraulicher Geschäftsinformationen vor rechtswidrigem Erwerb sowie rechtswidriger Nutzung und Offenlegung) umgesetzt. Der bisher dezentral und weitgehend unspezifiziert (§§ 823 ff., 826, 1004 BGB) bestehende Geheimnisschutz ist nunmehr einheitlich und übersichtlich zusammengefasst. Stefan Ernst gibt einen Überblick über die Neuerungen gegenüber der bisherigen Rechtslage und Anhaltspunkte für Handlungsbedarf bei betroffenen Unternehmen.
Leitsätze des Verfassers:
1. Art. 85 DSGVO erlaubt wie die Vorgängerregelung in Art. 9 RL 95/46/EG nationale Gesetze mit Abweichungen von der DSGVO zu Gunsten der Verarbeitung zu journalistischen Zwecken. Er enthält damit eine Öffnungsklausel, die nicht nur neue Gesetze erlaubt, sondern auch bestehende Regelungen – soweit sie sich einfügen – erfassen kann.
2. Die umfangreichen Abwägungsmöglichkeiten im Rahmen des KUG erlauben eine Berücksichtigung auch der unionsrechtlichen Grundrechtspositionen.
Anmerkung zu OLG Köln, Beschluss vom 18.06.2018 – 15 W 27/18 (rechtskräftig; LG Köln). DSGVO Art. 85; RL 95/46/EG Art. 9; BGB §§ 823, 1004; KUG §§ 22, 23
Urteilsausspruch (Verfahrenssprache: Deutsch):
Art. 16 lit. e RL 2011/83/EU ist dahin auszulegen, dass eine Ware wie eine Matratze, deren Schutzfolie vom Verbraucher nach der Lieferung entfernt wurde, nicht unter den Begriff „versiegelte Waren …, die aus Gründen des Gesundheitsschutzes oder aus Hygienegründen nicht zur Rückgabe geeignet sind und deren Versiegelung nach der Lieferung entfernt wurde“ im Sinne dieser Vorschrift fällt.
EuGH, Urteil vom 27.03.2019 – Rs C-681/17 (BGH), ZIP 2019, 715 (LS) = BB 2019, 769
Leitsatz des Gerichts:
Die Übermittlung eines „presserechtlichen Informationsschreibens“ greift in der Regel nicht rechtswidrig in das Recht am eingerichteten und ausgeübten Gewerbebetrieb eines Presseunternehmens ein. Eine andere Beurteilung ist allerdings dann geboten, wenn das übersandte Informationsschreiben von vornherein ungeeignet ist, präventiven Rechtsschutz zu bewirken. Hiervon ist auszugehen, wenn es keine Informationen enthält, die dem Presseunternehmen die Beurteilung erlauben, ob Persönlichkeitsrechte durch eine etwaige Berichterstattung verletzt werden.
BGB § 823 Abs. 1, § 1004; ZPO § 253. BGH, Urteil vom 15.01.2019 – VI ZR 506/17 (OLG Frankfurt/M.), MDR 2019, 290 = NJW 2019, 781 = WM 2019, 473
Urteilsausspruch (Verfahrenssprache: Deutsch):
1. Art. 6 Abs. 1 lit. c RL 2011/83/EU ist zum einen dahin auszulegen, dass er einer nationalen Regelung … entgegensteht, nach der ein Unternehmer verpflichtet ist, vor Abschluss eines Vertrags mit einem Verbraucher im Fernabsatz oder außerhalb von Geschäftsräumen i. S. v. Art. 2 Nr. 7 und 8 dieser RL stets seine Telefonnummer anzugeben. Zum anderen impliziert diese Bestimmung keine Verpflichtung des Unternehmers, einen Telefon- oder Telefaxanschluss bzw. ein E-Mail-Konto neu einzurichten, damit die Verbraucher mit ihm in Kontakt treten können. Sie verpflichtet den Unternehmer nur dann zur Übermittlung der Telefon- oder Telefaxnummer bzw. seiner E-Mail-Adresse, wenn er über diese Kommunikationsmittel mit den Verbrauchern bereits verfügt.
2. Art. 6 Abs. 1 lit. c RL 2011/83/EU ist dahin auszulegen, dass diese Bestimmung zwar den Unternehmer verpflichtet, dem Verbraucher ein Kommunikationsmittel zur Verfügung zu stellen, das geeignet ist, die Kriterien einer direkten und effizienten Kommunikation zu erfüllen, doch steht diese Bestimmung dem nicht entgegen, dass der Unternehmer andere Kommunikationsmittel als die in ihr genannten zur Verfügung stellt, um diese Kriterien zu erfüllen.
EuGH, Urteil vom 10.07.2019 – Rs C-649/17 (BGH), ZIP 2019, 1431
Urteilsausspruch (Verfahrenssprache: Deutsch):
Art. 2 lit. c RL 2002/21/EG des EU-Parlaments und des Rates vom 7. 3. 2002 über einen gemeinsamen Rechtsrahmen für elektronische Kommunikationsnetze und -dienste (Rahmenrichtlinie) in der durch die RL 2009/140/EG des EU-Parlaments und des Rates vom 25. 11. 2009 geänderten Fassung ist dahin auszulegen, dass ein internetbasierter E-Mail-Dienst, der wie der von der Google LLC erbrachte Dienst GMail keinen Internetzugang vermittelt, nicht ganz oder überwiegend in der Übertragung von Signalen über elektronische Kommunikationsnetze besteht und daher keinen „elektronischen Kommunikationsdienst“ im Sinne dieser Bestimmung darstellt.
EuGH, Urteil vom 13.06.2019 – Rs C-193/18 (OVG Münster), NJW 2019, 2597
Störerhaftung des beworbenen Unternehmens bei unverlangter E-Mail-Werbung durch beauftragten Dritten
(2019)
Leitsätze des Verfassers:
1. Ein Unternehmen, das einen Dritten mit der Durchführung von Werbeaktionen beauftragt, haftet für die unverlangte Zusendung von Werbe-E-Mails im Rahmen einer solchen Werbeaktion.
2. Der Adressat unverlangter E-Mail-Werbung hat auch dann einen datenschutzrechtlichen Auskunftsanspruch gegen das beworbene Unternehmen, wenn die Werbung durch eine Drittfirma durchgeführt wurde.
LG Frankenthal (Pfalz), Urteil vom 10.07.2018 – 6 O 322/17 (nicht rechtskräftig, Az. des OLG Zweibrücken 4 U 114/18)
Online-Zahlungssystem der Deutschen Bahn unionsrechtswidrig ("Verein für Konsumenteninformation")
(2019)
Urteilsausspruch (Verfahrenssprache: Deutsch):
Art. 9 Abs. 2 VO (EU) Nr. 260/2012 ist dahin auszulegen, dass er einer Vertragsklausel … entgegensteht, die die Zahlung mittels einer Lastschrift, die auf Euro lautet und über das in der EU bestehende Lastschriftverfahren vorgenommen wird (SEPA-Lastschrift), ausschließt, wenn der Zahler seinen Wohnsitz nicht in dem Mitgliedstaat hat, in dem der Zahlungsempfänger seinen Sitz hat.
EuGH, Urteil vom 05.09.2019 – Rs C-28/18 (EuGH GA ZIP 2019, 1272; Oberster Gerichtshof (Österreich)), ZIP 2019, 1760
Printed electronics (PE) is a fast growing technology with promising applications in wearables, smart sensors and smart cards since it provides mechanical flexibility, low-cost, on-demand and customizable fabrication. To secure the operation of these applications, True Random Number Generators (TRNGs) are required to generate unpredictable bits for cryptographic functions and padding. However, since the additive fabrication process of PE circuits results in high intrinsic variation due to the random dispersion of the printed inks on the substrate, constructing a printed TRNG is challenging. In this paper, we exploit the additive customizable fabrication feature of inkjet printing to design a TRNG based on electrolyte-gated field effect transistors (EGFETs). The proposed memory-based TRNG circuit can operate at low voltages (≤ 1 V ), it is hence suitable for low-power applications. We also propose a flow which tunes the printed resistors of the TRNG circuit to mitigate the overall process variation of the TRNG so that the generated bits are mostly based on the random noise in the circuit, providing a true random behaviour. The results show that the overall process variation of the TRNGs is mitigated by 110 times, and the simulated TRNGs pass the National Institute of Standards and Technology Statistical Test Suite.
Printed electronics (PE) circuits have several advantages over silicon counterparts for the applications where mechanical flexibility, extremely low-cost, large area, and custom fabrication are required. The custom (personalized) fabrication is a key feature of this technology, enabling customization per application, even in small quantities due to low-cost printing compared with lithography. However, the personalized and on-demand fabrication, the non-standard circuit design, and the limited number of printing layers with larger geometries compared with traditional silicon chip manufacturing open doors for new and unique reverse engineering (RE) schemes for this technology. In this paper, we present a robust RE methodology based on supervised machine learning, starting from image acquisition all the way to netlist extraction. The results show that the proposed RE methodology can reverse engineer the PE circuits with very limited manual effort and is robust against non-standard circuit design, customized layouts, and high variations resulting from the inherent properties of PE manufacturing processes.
Printed electronics can benefit from the deployment of electrolytesas gate insulators,which enables a high gate capacitance per unit area (1–10 μFcm−2) due to the formation of electrical double layers (EDLs). Consequently, electrolyte-gated field-effect transistors (EGFETs) attain high-charge carrier densities already in the subvoltage regime, allowing for low-voltage operation of circuits and systems. This article presents a systematic study of lumped terminal capacitances of printed electrolyte-gated transistors under various dc bias conditions. We perform voltage-dependent impedancemeasurements and separate extrinsic components from the lumped terminal capacitance.
The proposed Meyer-like capacitance model, which also accounts for the nonquasi-static (NQS) effect, agrees well with experimental data. Finally, to verify the model, we implement it in Verilog-A and simulate the transient response of an inverter and a ring oscillator circuit. Simulation results are in good agreement with the measurement data of fabricated devices.
Electrolyte-gated, printed field-effect transistors exhibit high charge carrier densities in the channel and thus high on-currents at low operating voltages, allowing for the low-power operation of such devices. This behavior is due to the high area-specific capacitance of the device, in which the electrolyte takes the role of the dielectric layer of classical architectures. In this paper, we investigate intrinsic double-layer capacitances of ink-jet printed electrolyte-gated inorganic field-effect transistors in both in-plane and top-gate architectures by means of voltage-dependent impedance spectroscopy. By comparison with deembedding structures, we separate the intrinsic properties of the double-layer capacitance at the transistor channel from parasitic effects and deduce accurate estimates for the double-layer capacitance based on an equivalent circuit fitting. Based on these results, we have performed simulations of the electrolyte cutoff frequency as a function of electrolyte and gate resistances, showing that the top-gate architecture has the potential to reach the kilohertz regime with proper optimization of materials and printing process. Our findings additionally enable accurate modeling of the frequency-dependent capacitance of electrolyte/ion gel-gated devices as required in the small-signal analysis in the circuit simulation.
Grundlagen der Organisation
(2019)
Eine betriebswirtschaftliche Theorie der Organisationsgestaltung hat Strukturmodelle zu entwickeln, die als Grundlage für Organisationsentscheidungen des Managements geeignet sind. Es geht dabei um die Bewältigung der elementaren Anforderungen, die bei interpersoneller Arbeitsteilung zwangsläufig durch die Trennung zusammenhängender Aufgabenkomplexe und die Einbeziehung einer Mehrzahl von Personen mit jeweils individuellen Zielen entstehen. Bei der Verfolgung dieses Anliegens orientiert sich auch die Neuauflage der "Grundlagen der Organisation" unverändert am bewährten entscheidungstheoretischen Konzept der Organisationsgestaltung, das einen fundierten anwendungsbezogen Zugang zum Verständnis und zur Lösung komplexer Organisationsprobleme eröffnet.
Robots and automata are key elements of every vision and forecast of life in the near and distant future. However, robots and automata also have a long history, which reaches back into antiquity. Today most historians think that one of the key roles of robots and automata was to amaze or even terrify the audience: They were designed to express something mythical, magical, and not explainable. Moreover, the visions of robots and their envisioned fields of application reflect the different societies. Therefore, this short history of robotics and (especially) anthropomorphic automata aims to give an overview of several historical periods and their perspective on the topic. In a second step, this work aims to encourage readers to reflect on the recent discussion about fields of application as well as the role of robotics today and in the future.
A novel Bluetooth Low Energy advertising scan algorithm is presented for hybrid radios that are additionally capable to measure energy on Bluetooth channels, e.g. as they would need to be compliant with IEEE 802.15.4. Scanners applying this algorithm can achieve a low latency whilst consuming only a fraction of the power that existing mechanisms can achieve at a similar latency. Furthermore, the power consumption can scale with the incoming network traffic and in contrast to the existing mechanisms, scanners can operate without any frame loss given ideal network conditions. The algorithm does not require any changes to advertisers, hence, stays compatible with existing devices. Performance evaluated via simulation and experiments on real hardware shows a 37 percent lower power consumption compared to the best existing scan setting while even achieving a slightly lower latency which proves that this algorithm can be used to improve the quality of service of connection-less Bluetooth communication or reduce the connection establishment time of connection-oriented communication.
We present a novel approach that utilizes BLE packets sent from generic BLE capable radios to synthesize an FSK-(like) addressable wake-up packet. A wake-up receiver system was developed from off-the-shelf components to detect these packets. It makes use of two differential signal paths separated by passive band-pass filters. After the rectification of each channel a differential amplifier compares the signals and the resulting wake-up signal is evaluated by an AS3933 wake-up receiver IC. Overall, the combination of these techniques contributes to a BLE compatible wake-up system which is more robust than traditional OOK wake-up systems. Thus, increasing wake-up range, while still maintaining a low energy budget. The proof-of-concept setup achieved a sensitivity of -47.8 dBm at a power consumption of 18.5 uW during passive listening. The system has a latency of 31.8 ms with a symbol rate of 1437 Baud.
Die Vorlesung Physik ist ein grundlegender Baustein der meisten Ingenieursstudiengänge und stellt für viele Studienanfänger eine Hürde zum Studienstart da. Die Vorkenntnisse der Studienanfänger sind zunehmend heterogen und der sichere Umgang mit physikalischen Konzepten erfordert mehr oder wenig Übung, um diese zu festigen oder auch erstmals einzuführen. Um dieses Üben zu ermöglichen, wurde für die Vorlesung "Physik 1" in den Studiengängen Maschinenbau, Werkstofftechnik, Mechatronik, Biomechanik, Biotechnologie und Umwelt- und Verfahrenstechnik der Hochschule Offenburg ein E-Tutorium erarbeitet, das die Übungsaufgaben in Form von 10 Online-Selbsttest mit jeweils vier Übungsaufgaben anbietet. Die Selbsttests beinhalten dabei typische Aufgabenstellungen, deren Zahlenwerte (Masse, Geschwindigkeit usw.) bei jedem Aufruf der Aufgabe variieren. Dadurch lassen sich die Selbsttests zum selbständigen Üben nutzen. Ein reines Abschreiben einer Musterlösung ist durch die veränderlichen Zahlenwerte darüber hinaus unmöglich. Wir beschreiben eine Methode zur effizienten Erzeugung der Moodle-basierten Selbsttests mit Hilfe der Software R/exams und berichten über die Erfahrungen beim ersten Einsatz.
Brückenkurs Physik
(2019)
Dieses Lehrbuch fasst alle wesentlichen, für das Studium eines MINT-Faches relevanten Inhalte der Physik zusammen und hilft physikalisches Grundwissen aufzufrischen. Es unterstützt Studienanfänger dabei, die Routine in der konkreten Anwendung, die an der Hochschule vorausgesetzt wird, zu festigen. Dabei folgt die Stoffauswahl dem Mindestanforderungskatalog Physik, den ein Arbeitskreis aus Professoren der baden-württembergischen Hochschulen für angewandte Wissenschaften zusammengestellt hat.
Tryptamines can occur naturally in plants, mushrooms, microbes, and amphibians. Synthetic tryptamines are sold as new psychoactive substances (NPS) because of their hallucinogenic effects. When it comes to NPS, metabolism studies are of crucial importance, due to the lack of pharmacological and toxicological data. Different approaches can be taken to study in vitro and in vivo metabolism of xenobiotica. The zygomycete fungus Cunninghamella elegans (C. elegans) can be used as a microbial model for the study of drug metabolism. The current study investigated the biotransformation of four naturally occurring and synthetic tryptamines [N,N‐Dimethyltryptamine (DMT), 4‐hydroxy‐N‐methyl‐N‐ethyltryptamine (4‐HO‐MET), N,N‐di allyl‐5‐methoxy tryptamine (5‐MeO‐DALT) and 5‐methoxy‐N‐methyl‐N‐isoporpoyltryptamine (5‐MeO‐MiPT)] in C. elegans after incubation for 72 hours. Metabolites were identified using liquid chromatography–high resolution–tandem mass spectrometry (LC–HR–MS/MS) with a quadrupole time‐of‐flight (QqTOF) instrument. Results were compared to already published data on these substances. C. elegans was capable of producing all major biotransformation steps: hydroxylation, N‐oxide formation, carboxylation, deamination, and demethylation. On average 63% of phase I metabolites found in the literature could also be detected in C. elegans. Additionally, metabolites specific for C. elegans were identified. Therefore, C. elegans is a suitable complementary model to other in vitro or in vivo methods to study the metabolism of naturally occurring or synthetic tryptamines.
Synergieprognosen spielen bei der Begründung von Unternehmensübernahmen regelmäßig eine wichtige Rolle. Da diese Prognosen unsicher sind, bedürfen sie einer fundierten Beurteilung, was wiederum eine offene Diskussion innerhalb von Vorstand und Aufsichtsrat voraussetzt. Solche Diskussionen sind jedoch keine Selbstverständlichkeit, da Gruppen dazu neigen, problematische Entscheidungsaspekte nicht angemessen zu würdigen. Mit dem Tornado-Diagramm wird ein Instrument vorgestellt, das diesem Effekt entgegenwirkt und die Entscheider dazu motiviert, auch ungünstige Synergieprognosen zu diskutieren. Auf diese Weise kann die Übernahmeentscheidung auf eine bessere Informationsgrundlage gestellt werden.
Background: Transesophageal left atrial (LA) pacing and transesophageal LA ECG recording are semi-invasive techniques for diagnostic and therapy of supraventricular rhythm disturbance. Cardiac resynchronization therapy (CRT) with right atrial (RA) sensed biventricular pacing is an established therapy for heart failure patients with reduced left ventricular (LV) ejection fraction, sinus rhythm and interventricular electrical desynchronization.
Purpose: The aim of the study was to evaluate electromagnetic and voltage pacing fields of the combination of RA pacing, LA pacing and biventricular pacing in patients with long interatrial and interventricular electrical desynchronization.
Methods: The modelling and electromagnetic simulations of transesophageal LA pacing in combination with RA pacing and biventricular pacing would be staged and analyzed with the CST (Computer Simulation Technology) software. Different electrodes were modelled in order to simulate different types of bipolar pacing in the 3D-CAD Offenburg heart rhythm model: The bipolar Solid S (Biotronik) electrode where modelled for RA pacing and right ventricular (RV) pacing, Attain 4194 (Medtronic) for LV pacing and TO8 (Osypka) multipolar esophageal electrode with hemispheric electrodes for LA pacing.
Results: The pacemaker amplitudes for the electromagnetic pacing simulations were performed with 3 V for RA pacing, 1.5 V for RV pacing, 50 V for LA pacing and 3V for LV pacing with pacing impulse duration of 0.5 ms for RA, RV and LV pacing and 10 ms for LA pacing. The atrioventricular pacing delay after RA pacing was 140 ms. The different pacing modes AAI, VVI, DDD, DDD0V and DDD0D were evaluated for the analysis of the electric pacing field propagation of pacemaker, CRT and LA pacing. The pacing results were compared at minimum (LOW) and maximum (HIGH) parameter settings. While the LOW setting produced fewer tetrahedral and more inaccurate results, the HIGH setting produced many tetrahedral and therefore more accurate results.
Conclusions: The simulation of the combination of transesophageal LA pacing with RA sensed biventricular pacing is possible with the Offenburg heart rhythm model. The new temporary 4-chamber pacing method may be additional useful method in CRT non-responders with long interatrial electrical delay.
In recent times, the energy consumed by buildings facilities became considerable. Efficient local energy management is vital to deal with building power demand penalties. This operation becomes complex when a hybrid energy system is included in the power system. This study proposes new energy management between photovoltaic (PV) system, Battery Energy Storage System (BESS) and the power network in a building by controlling the PV/BESS inverter. The strategy is based on explicit model predictive control (MPC) to find an optimal power flow in the building for one-day ahead. The control algorithm is based on a simple power flow equation and weather forecast. Then, a cost function is formulated and optimised using genetic algorithms-based solver. The objective is reducing the imported energy from the grid preventing the saturation and emptiness of BESS. Including other targets to the control policy as energy price dynamic and BESS degradation, MPC can optimise dramatically the efficacy of the global building power system. The strategy is implemented and tested successfully using MATLAB/SimPowerSystems software, compared to classical hysteresis management, MPC has given 10% in energy cost economy and 25% improvement in BESS lifetime.
Es wird eine Fallstudie vorgestellt, die die Visualisierung von Geschäftsdaten nach dem International Business Communication Standard IBCS (Hichert & Faisst 2016 / 2017) auf der cloudbasierten Plattform SAP Analytics Cloud umsetzt. Mit der Fallstudie soll die Frage beantwortet werden, ob IBCS im Rahmen einer Lehreinheit mit hohem praktischem Anteil mit SAP Analytics Cloud umgesetzt werden kann. Darüber hinaus soll der generelle Einsatz von SAP Analytics Cloud für die Lehre im Analytics-Umfeld evaluiert werden.
Einleitung
(2019)
High temperature components in internal combustion engines and exhaust systems must withstand severe mechanical and thermal cyclic loads throughout their lifetime. The combination of thermal transients and mechanical load cycling results in a complex evolution of damage, leading to thermomechanical fatigue (TMF) of the material. Analytical tools are increasingly employed by designers and engineers for component durability assessment well before any hardware testing. The DTMF model for TMF life prediction, which assumes that micro-crack growth is the dominant damage mechanism, is capable of providing reliable predictions for a wide range of high-temperature components and materials in internal combustion engines. Thus far, the DTMF model has employed a local approach where surface stresses, strains, and temperatures are used to compute damage for estimating the number of cycles for a small initial defect or micro-crack to reach a critical length. In the presence of significant gradients of stresses, strains, and temperatures, the use of surface field values could lead to very conservative estimates of TMF life when compared with reported lives from hardware testing. As an approximation of gradient effects, a non-local approach of the DTMF model is applied. This approach considers through-thickness fields where the micro-crack growth law is integrated through the thickness considering these variable fields. With the help of software tools, this method is automated and applied to components with complex geometries and fields. It is shown, for the TMF life prediction of a turbocharger housing, that the gradient correction using the non-local approach leads to more realistic life predictions and can distinguish between surface cracks that may arrest or propagate through the thickness and lead to component failure.
Neuroprosthetics 2.0
(2019)