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This thesis deals with the redesign of manufacturing systems by simulation and optimization. Material flow simulation is a common tool for solving problems in system design. Limitations are the high requirements in time and knowledge to execute simulation studies, evaluate results and solve design problems. New chances arrives with the technologies of industry 4.0 and the digital shadow, providing data for simulation. However, the methods to use production data for the redesign of production systems are not available yet. Purpose of this work is providing the methods to automate simulation from digital shadow, use simulation to optimize and solve problems in system design. Two case studies are used to support the action research approach of this work. The result of this work is a framework for the application of the digital shadow in optimization and problem-solving.