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The authors present an abiotically catalyzed glucose fuel cell and demonstrate its application as energy harvesting power source for a cardiac pacemaker. This is enabled by an optimized DC-DC converter operating at 40 % conversion efficiency, which surpasses commercial low-power DC-DC converters. The required fuel cell surface area can thus be reduced from about 125 cm2 to 18 cm2, which would allow for its direct integration onto the pacemaker casing.