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This paper presents the elements and the results from the European research project inCASA (Integrated Network for Completely Assisted Senior Citizen’s Autonomy), which designed and implemented a seamless integration of heterogeneous systems and network protocols for regionally distributed telecare and telehealth applications. The integration includes a multitude of physical interface, the transcoding of data models using embedded middleware, and a backend system with open interfaces. The implementation was verified in field tests in five European countries.