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Background: Many countries have restricted public life in order to contain the spread of the novel coronavirus (SARS-CoV2). As a side effect of related measures, physical activity (PA) levels may have decreased.
Objective: We aimed (1) to quantify changes in PA and (2) to identify variables potentially predicting PA reductions.
Methods: A systematic review with random-effects multilevel meta-analysis was performed, pooling the standardized mean differences in PA measures before and during public life restrictions.
Results: A total of 173 trials with moderate methodological quality (modified Downs and Black checklist) were identified. Compared to pre-pandemic, total PA (SMD − 0.65, 95% CI − 1.10 to − 0.21) and walking (SMD − 0.52, 95% CI − 0.29 to − 0.76) decreased while sedentary behavior increased (SMD 0.91, 95% CI: 0.17 to 1.65). Reductions in PA affected all intensities (light: SMD − 0.35, 95% CI − 0.09 to − 0.61, p = .013; moderate: SMD − 0.33, 95% CI − 0.02 to − 0.6; vigorous: SMD − 0.33, − 0.08 to − 0.58, 95% CI − 0.08 to − 0.58) to a similar degree. Moderator analyses revealed no influence of variables such as sex, age, body mass index, or health status. However, the only continent without a PA reduction was Australia and cross-sectional trials yielded higher effect sizes (p < .05).
Conclusion: Public life restrictions associated with the COVID-19 pandemic resulted in moderate reductions in PA levels and large increases in sedentary behavior. Health professionals and policy makers should therefore join forces to develop strategies counteracting the adverse effects of inactivity.
Immunosorbent turnip vein clearing virus (TVCV) particles displaying the IgG-binding domains D and E of Staphylococcus aureus protein A (PA) on every coat protein (CP) subunit (TVCVPA) were purified from plants via optimized and new protocols. The latter used polyethylene glycol (PEG) raw precipitates, from which virions were selectively re-solubilized in reverse PEG concentration gradients. This procedure improved the integrity of both TVCVPA and the wild-type subgroup 3 tobamovirus. TVCVPA could be loaded with more than 500 IgGs per virion, which mediated the immunocapture of fluorescent dyes, GFP, and active enzymes. Bi-enzyme ensembles of cooperating glucose oxidase and horseradish peroxidase were tethered together on the TVCVPA carriers via a single antibody type, with one enzyme conjugated chemically to its Fc region, and the other one bound as a target, yielding synthetic multi-enzyme complexes. In microtiter plates, the TVCVPA-displayed sugar-sensing system possessed a considerably increased reusability upon repeated testing, compared to the IgG-bound enzyme pair in the absence of the virus. A high coverage of the viral adapters was also achieved on Ta2O5 sensor chip surfaces coated with a polyelectrolyte interlayer, as a prerequisite for durable TVCVPA-assisted electrochemical biosensing via modularly IgG-assembled sensor enzymes.
Predictive control has great potential in the home energy management domain. However, such controls need reliable predictions of the system dynamics as well as energy consumption and generation, and the actual implementation in the real system is associated with many challenges. This paper presents the implementation of predictive controls for a heat pump with thermal storage in a real single-family house with a photovoltaic rooftop system. The predictive controls make use of a novel cloud camera-based short-term solar energy prediction and an intraday prediction system that includes additional data sources. In addition, machine learning methods were used to model the dynamics of the heating system and predict loads using extensive measured data. The results of the real and simulated operation will be presented.
Over the last few decades, several grid coupling techniques for hierarchically refined Cartesian grids have been developed to provide the possibility of varying mesh resolution in lattice Boltzmann methods. The proposed schemes can be roughly categorized based on the individual grid transition interface layout they are adapted to, namely cell-vertex or cell-centered approaches, as well as a combination of both. It stands to reason that the specific properties of each of these grid-coupling algorithms influence the stability and accuracy of the numerical scheme. Consequently, this naturally leads to a curiosity regarding the extent to which this is the case. The present study compares three established grid-coupling techniques regarding their stability ranges by conducting a series of numerical experiments for a square duct flow, including various collision models. Furthermore the hybrid-recursive regularized collision model, originally introduced for cell-vertex algorithms with co-located coarse and fine grid nodes, has been adapted to cell-centered and combined methods.
Lithium-ion battery cells exhibit a complex and nonlinear coupling of thermal, electrochemical,and mechanical behavior. In order to increase insight into these processes, we report the development of a pseudo-three-dimensional (P3D) thermo-electro-mechanical model of a commercial lithium-ion pouch cell with graphite negative electrode and lithium nickel cobalt aluminum oxide/lithium cobalt oxide blend positive electrode. Nonlinear molar volumes of the active materials as function of lithium stoichiometry are taken from literature and implemented into the open-source software Cantera for convenient coupling to battery simulation codes. The model is parameterized and validated using electrical, thermal and thickness measurements over a wide range of C-rates from 0.05 C to 10 C. The combined experimental and simulated analyses show that thickness change during cycling is dominated by intercalation-induced swelling of graphite, while swelling of the two blend components partially cancel each other. At C-rates above 2 C, electrochemistry-induced temperature increase significantly contributes to cell swelling due to thermal expansion. The thickness changes are nonlinearly distributed over the thickness of the electrode pair due to gradients in the local lithiation, which may accelerate local degradation. Remaining discrepancies between simulation and experiment at high C-rates might be attributed to lithium plating, which is not considered in the model at present.
In this paper, a temperature-dependent viscoplasticity model is presented that describes thermal and cyclic softening of the hot work steel X38CrMoV5-3 under thermomechanical fatigue loading. The model describes the softening state of the material by evolution equations, the material properties of which can be determined on the basis of a defined experimental program. A kinetic model is employed to capture the effect of coarsening carbides and a new isotropic cyclic softening model is developed that takes history effects during thermomechanical loadings into account. The temperature-dependent material properties of the viscoplasticity model are determined on the basis of experimental data measured in isothermal and thermomechanical fatigue tests for the material X38CrMoV5-3 in the temperature range between 20 and 650 ∘C. The comparison of the model and an existing model for isotropic softening shows an improved description of the softening behavior under thermomechanical fatigue loading. A good overall description of the experimental data is possible with the presented viscoplasticity model, so that it is suited for the assessment of operating loads of hot forging tools.
A novel method for quasi-continuous tar monitoring in hot syngas from biomass gasification is reported. A very small syngas stream is extracted from the gasifier output, and the oxygen demand for tar combustion is determined by a well-defined dosage of synthetic air. Assuming the total oxidation of all of the combustible components at the Pt-electrode of a lambda-probe, the difference of the residual oxygen concentrations from successive operations with and without tar condensation represents the oxygen demand. From experiments in the laboratory with H2/N2/naphthalene model syngas, the linear sensitivity and a lower detection limit of about 70 ± 5 mg/m3 was estimated, and a very good long-term stability can be expected. This extremely sensitive and robust monitoring concept was evaluated further by the extraction of a small, constant flow of hot syngas as a sample (9 L/h) using a Laval nozzle combined with a metallic filter (a sintered metal plate (pore diameter 10 µm)) and a gas pump (in the cold zone). The first tests in the laboratory of this setup—which is appropriate for field applications—confirmed the excellent analysis results. However, the field tests concerning the monitoring of the tar in syngas from a woodchip-fueled gasifier demonstrated that the determination of the oxygen demand by the successive estimation of the oxygen concentration with/without tar trapping is not possible with enough accuracy due to continuous variation of the syngas composition. A method is proposed for how this constraint can be overcome.
Injury prevention is essential in running due to the risk of overuse injury development. Tailoring running shoes to individual needs may be a promising strategy to reduce this risk. Novel manufacturing processes allow the production of individualised running shoes that incorporate features that meet individual biomechanical and experiential needs. However, specific ways to individualise footwear to reduce injury risk are poorly understood. Therefore, this scoping review provides an overview of (1) footwear design features that have the potential for individualisation; and (2) the literature on the differential responses to footwear design features between selected groups of individuals. These purposes focus exclusively on reducing the risk of overuse injuries. We included studies in the English language on adults that analysed: (1) potential interaction effects between footwear design features and subgroups of runners or covariates (e.g., age, sex) for running-related biomechanical risk factors or injury incidences; (2) footwear comfort perception for a systematically modified footwear design feature. Most of the included articles (n = 107) analysed male runners. Female runners may be more susceptible to footwear-induced changes and overuse injury development; future research should target more heterogonous sampling. Several footwear design features (e.g., midsole characteristics, upper, outsole profile) show potential for individualisation. However, the literature addressing individualised footwear solutions and the potential to reduce biomechanical risk factors is limited. Future studies should leverage more extensive data collections considering relevant covariates and subgroups while systematically modifying isolated footwear design features to inform footwear individualisation.
Non-contact anterior cruciate ligament injuries typically occur during cutting maneuvers and are associated with high peak knee abduction moments (KAM) within early stance. To screen athletes for injury risk or quantify the efficacy of prevention programs, it may be necessary to design tasks that mimic game situations. Thus, this study compared KAMs and ranking consistency of female handball players in three sport-specific fake-and-cut tasks of increasing complexity. The biomechanics of female handball players (n = 51, mean ± SD: 66.9 ± 7.8 kg, 1.74 ± 0.06 m, 19.2 ± 3.4 years) were recorded with a 3D motion capture system and force plates during three standardized fake-and-cut tasks. Task 1 was designed as a simple pre-planned cut, task 2 included catching a ball before a pre-planned cut in front of a static defender, and task 3 was designed as an unanticipated cut with three dynamic defenders involved. Inverse dynamics were used to calculate peak KAM within the first 100 ms of stance. KAM was decomposed into the frontal plane knee joint moment arm and resultant ground reaction force. RANOVAs (α ≤ 0.05) were used to reveal differences in the KAM magnitudes, moment arm, and resultant ground reaction force for the three tasks. Spearman's rank correlations were calculated to test the ranking consistency of the athletes' KAMs. There was a significant task main effect on KAM (p = 0.02; ηp2 = 0.13). The KAM in the two complex tasks was significantly higher (task 2: 1.73 Nm/kg; task 3: 1.64 Nm/kg) than the KAM in the simplest task (task 1: 1.52 Nm/kg). The ranking of the peak KAM was consistent regardless of the task complexity. Comparing tasks 1 and 2, an increase in KAM resulted from an increased frontal plane moment arm. Comparing tasks 1 and 3, higher KAM in task 3 resulted from an interplay between both moment arm and the resultant ground reaction force. In contrast to previous studies, unanticipated cutting maneuvers did not produce the highest KAMs. These findings indicate that the players have developed an automated sport-specific cutting technique that is utilized in both pre-planned and unanticipated fake-and-cut tasks.
Heat pumps play a central role in decarbonizing the heat supply of buildings. However, in this article, implementing heat pumps in existing buildings, a significant challenge is still presented due to high temperature requirements. In this article, a systematic analysis of the effects of heat source temperatures, maximum heat pump condenser temperatures, and system temperatures on the seasonal performance of heat pump (HP) systems is presented. The quantitative performance analysis encompasses over 50 heat pumps installed in residential buildings, revealing correlations between the building characteristics, observed temperatures, and heat pump type. The performance of an HP system retrofitted to a 30-dwelling multifamily building is presented in more detail. The bivalent HP system combines air and ground as heat sources and achieves a seasonal performance factor of 3.25 with a share of the gas boiler of 27% in its first year of operation. In these findings, the technical feasibility of retrofitting heat pumps is demonstrated in existing buildings and insights are provided into overcoming the challenges associated with high temperature requirements.