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The aim of this study was to develop a biomechanically validated finite element model to predict the biomechanical behaviour of the human lumbar spine in compression.
For validation of the finite element model, an in vitro study was performed: Twelve human lumbar cadaveric spinal segments (six segments L2/3 and six segments L4/5) were loaded in axial compression using 600 N in the intact state and following surgical treatment using two different internal stabilisation devices. Range of motion was measured and used to calculate stiffness.
A finite element model of a human spinal segment L3/4 was loaded with the same force in intact and surgically altered state, corresponding to the situation of biomechanical in vitro study.
The results of the cadaver biomechanical and finite element analysis were compared. As they were close together, the finite element model was used to predict: (1) load-sharing within human lumbar spine in compression, (2) load-sharing within osteoporotic human lumbar spine in compression and (3) the stabilising potential of the different spinal implants with respect to bone mineral density.
A finite element model as described here may be used to predict the biomechanical behaviour of the spine. Moreover, the influence of different spinal stabilisation systems may be predicted.
A systematic toxicological analysis procedure using high-performance thin layer chromatography in combination with fibre optical scanning densitometry for identification of drugs in biological samples is presented. Two examples illustrate the practicability of the technique. First, the identification of a multiple intake of analgesics: codeine, propyphenazone, tramadol, flupirtine and lidocaine, and second, the detection of the sedative diphenhydramine. In both cases, authentic urine specimens were used. The identifications were carried out by an automatic measurement and computer-based comparison of in situ UV spectra with data from a compiled library of reference spectra using the cross-correlation function. The technique allowed a parallel recording of chromatograms and in situ UV spectra in the range of 197–612 nm. Unlike the conventional densitometry, a dependency of UV spectra by concentration of substance in a range of 250–1000 ng/spot was not observed.
Vom Tragverhalten und von der Geometrie (eben oder gekrümmt, linien- oder flächenhaft ausgeprägt) her unterscheidet man Sandwich-Balken, Sandwich-Platten, -Scheiben und -Schalen. Im Normalfall hat man ein Zusammenwirken aus drei Schichten: Den zug- bzw. druckaufnehmenden Deckschichten und der schubbelasteten Kernschicht. Die Klebverbindung von Kern- und der jeweiligen Deckschicht hat mindestens die kraftübertragende Eigenschaft der schwächsten Schicht (d.h. der Schicht mit dem kleinsten E-Modul) aufzuweisen. Dies ist in der Regel die Kernschicht. Diese Eigenschaft der Verklebung muss über die Lebensdauer des Tragwerkes erhalten bleiben. Bei rein statischer Belastung sind die Verklebung in ihrer Zeitfestigkeit und das Lastkriechen der schubaufnehmenden Kernschicht zu beachten. Bei dynamischer Belastung sind die entsprechenden Wöhler-Kurven zu beachten. Viele Klebstoffe sind dynamisch belastbar. Wenn man die Festigkeits- und Steifigkeitsberechnung durchführen möchte, kann die so genannte exakte Berechnungsmethode über gekoppelte partielle Differenzialgleichungen zum Ziel führen. Neben der Berechnung der Verformungen und Spannungen infolge Platten- und Scheibenwirkung kommen bei hochbelasteten gekrümmten Sandwich-Bauteilen auch die Koppelgleichungen von Platte und Scheibe zur Schale hinzu. Außerdem kommt bei dünnen, unter Druck stehenden Deckschichten die Abschätzung der Knitterspannungen hinzu, die ja nach der Bettung der Deckschicht auf der Kernschicht weitestgehend von der Dehnsteifigkeit der Kernschicht abhängt. Seit den 60-er Jahren hat sich die Finite-Elemente-Methode als eine computergestützte Berechnungsmethode etabliert, die zwar als Näherungsmethode definiert ist aber eine hervorragende Genauigkeit in der Spannungs- und Steifigkeitsberechnung bietet.
The bandwidth behavior of graded-index multimode fibers (GI-MMFs) for different launching conditions is investigated to understand and characterize the effect of differential mode delay. In order to reduce the launch-power distribution the near field of a single-mode fiber is used to produce a controlled restricted launch. The baseband response is measured by observing the broadening of a narrow input pulse (time-domain measurement). The paper verifies the degradation in bandwidth due to profile distortion by scanning the spot of the single-mode fiber with a transversal offset from the center of the test sample. In addition, the impact of the launch-power distribution tuned by different spot-size diameters is demonstrated. Measurements were taken on ‘older’ 50-μm and 62.5-μm GI-MMFs as well as on laser-performance-optimized fibers more recently developed.
High performance thin layer chromatography (HPTLC) is a frequently used separation technique which works well for quantification of caffeine and quinine in beverages. Competing separation techniques, e.g. high-performance liquid chromatography (HPLC) or gas chromatography (GC), are not suitable for sugar-containing samples, because these methods need special pretreatment by the analyst. In HPTLC, however, it is possible to separate ‘dirty’ samples without time-consuming pretreatment, because disposable HPTLC plates are used. A convenient method for quantification of caffeine and quinine in beverages, without sample pretreatment, is presented below. The basic theory of in-situ quantification in HPTLC by use of remitted light is introduced and discussed. Several linearization models are discussed.
A home-made diode-array scanner has been used for quantification; this, for the first time, enables simultaneous measurements at different wavelengths. The new scanner also enables fluorescence evaluation without further equipment. Simultaneous recording at different wavelengths improves the accuracy and reliability of HPTLC analysis. These aspects result in substantial improvement of in-situ quantitative densitometric analysis and enable quantification of compounds in beverages.
HPTLC (High Performance Thin Layer Chromatography) is a well known and versatile separation method which shows a lot of advantages and options in comparison to other separation techniques. The method is fast and inexpensive and does not need time-consuming pretreatments. Using fiber-optic elements for controlled light-guiding, the TLC-method was significantly improved: the new HPTLC-system is able to measure simultaneously at different wavelengths without destroying the plate surface or the analytes on the surface. For registration of the sample distribution on a HPTLC-plate we developed a new and sturdy diode-array HPTLC- scanner which allows registration of spectra on the TLC- plates in the range of 198 nm to 610 nm with a spectral resolution better than 1.2 nm. The spatial resolution on plate is better than 160 micrometers . In the spectral mode, the new HPTLC-scanner delivers much more information than the commonly used TLC-scanner. The measurement of 450 spectra of one separation track does not need more than three minutes. However, in the fixed wavelength mode the contour plot can be measured within 15 seconds. In this case, the signal will be summarized and averaged over a spectral range having FWHM from 10 nm to 25 nm depending on the substance under test. The new diode-array HPTLC-scanner makes various chemometric applications possible. The new method can be used easily in clinical diagnostic systems easily, e.g. for blood and uring investigations. In addition, new applications are possible. For example, the rich structured PAHs were studied. Although the separation is incomplete the 16 compounds can be quantified using suitable wavelengths.
MPC-Workshop Januar 2002
(2002)
MPC-Workshop Juni 2002
(2002)
Ein neuer Ansatz wurde für mobile Roboter zur gleichzeitigen 3D (Drei-Dimensionaler) Kartierung und Lokalisierung vorgestellt. Die Grundlage bilden attributierte Flächenmodelle, die z.B. von segmentierten Laserscanner-Tiefenbildern stammen. Zur Optimierung der Gesamtähnlichkeit zwischen Flächenmodellen unter Zeitbedingungen werden mehrere Verfahren (Beschränkte Baumsuche, Iterative Verfeinerung, Evolutionäralgorithmus) kombiniert. Es wird speziell anhand der Ähnlichkeitsmaße gezeigt, wie das Wissen über die Lage stufenweise generiert und verwendet wird. Erste Messungen an realen segmentierten Tiefenbildfolgen zeigen, dass das Verfahren unbekannte übelappung, Verdeckung und Segmentierungsfehler toleriert sowie Echtzeitpotenzial besitzt.