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Background
To assess the in-field walking mechanics during downhill hiking of patients with total knee arthroplasty five to 14 months after surgery and an age-matched healthy control group and relate them to the knee flexor and extensor muscle strength.
Methods
Participants walked on a predetermined hiking trail at a self-selected, comfortable pace wearing an inertial sensor system for recording the whole-body 3D kinematics. Sagittal plane hip, knee, and ankle joint angles were evaluated over the gait cycle at level walking and two different negative slopes. The concentric and eccentric lower extremity muscle strength of the knee flexors and extensors isokinetically at 50 and 120°/s were measured.
Findings
Less knee flexion angles during stance have been measured in patients in the operated limb compared to healthy controls in all conditions (level walking, moderate downhill, steep downhill). The differences increased with steepness. Muscle strength was lower in patients for both muscle groups and all measured conditions. The functional hamstrings to quadriceps ratio at 120°/sec correlated with knee angle during level and downhill walking at the moderate slope in patients, showing higher ratios with lower peak knee flexion angles.
Interpretation
The study shows that even if rehabilitation has been completed successfully and complication-free, five to 14 months after surgery, the muscular condition was still insufficient to display a normal gait pattern during downhill hiking. The muscle balance between quadriceps and hamstring muscles seems related to the persistence of a stiff knee gait pattern after knee arthroplasty. LoE: III.
The aim of this paper is to identify indicators at country level that could prove useful in improving the effectiveness of fraud detection in European Structural and Investment Funds. We analyse data for 454 funds, belonging to the period 2014-2020, from the 28 countries that were members of the European Union in 2014. Explanatory results suggest the convenience of tracking funds, especially in countries with higher GDP and higher transparency levels, and the lesser relevance of the number of irregularities for countries with higher GDP and those receiving larger funds. Fraud and fraud detection rates in individual funds vary significantly across states. Federal states, such as the Federal Republic of Germany, are comparatively successful in detecting fraud in EU funds.
Purpose
This study aims to investigate a systematic approach to the production and use of additively manufactured injection mould inserts in product development (PD) processes. For this purpose, an evaluation of the additive tooling design method (ATDM) is performed.
Design/methodology/approach
The evaluation of the ATDM is conducted within student workshops, where students develop products and validate them using AT-prototypes. The evaluation process includes the analysis of work results as well as the use of questionnaires and participant observation.
Findings
This study shows that the ATDM can be successfully used to assist in producing and using AT mould inserts to produce valid AT prototypes. As a reference for the implementation of AT in industrial PD, extracts from the work of the student project groups and suitable process parameters for prototype production are presented.
Originality/value
This paper presents the application and evaluation of a method to support AT in PD that has not yet been scientifically evaluated.
An in-depth study of U-net for seismic data conditioning: Multiple removal by moveout discrimination
(2024)
Seismic processing often involves suppressing multiples that are an inherent component of collected seismic data. Elaborate multiple prediction and subtraction schemes such as surface-related multiple removal have become standard in industry workflows. In cases of limited spatial sampling, low signal-to-noise ratio, or conservative subtraction of the predicted multiples, the processed data frequently suffer from residual multiples. To tackle these artifacts in the postmigration domain, practitioners often rely on Radon transform-based algorithms. However, such traditional approaches are both time-consuming and parameter dependent, making them relatively complex. In this work, we present a deep learning-based alternative that provides competitive results, while reducing the complexity of its usage, and, hence simplifying its applicability. Our proposed model demonstrates excellent performance when applied to complex field data, despite it being exclusively trained on synthetic data. Furthermore, extensive experiments show that our method can preserve the inherent characteristics of the data, avoiding undesired oversmoothed results, while removing the multiples from seismic offset or angle gathers. Finally, we conduct an in-depth analysis of the model, where we pinpoint the effects of the main hyperparameters on real data inference, and we probabilistically assess its performance from a Bayesian perspective. In this study, we put particular emphasis on helping the user reveal the inner workings of the neural network and attempt to unbox the model.
A novel peptidyl-lys metalloendopeptidase (Tc-LysN) from Tramates coccinea was recombinantly expressed in Komagataella phaffii using the native pro-protein sequence. The peptidase was secreted into the culture broth as zymogen (~38 kDa) and mature enzyme (~19.8 kDa) simultaneously. The mature Tc-LysN was purified to homogeneity with a single step anion-exchange chromatography at pH 7.2. N-terminal sequencing using TMTpro Zero and mass spectrometry of the mature Tc-LysN indicated that the pro-peptide was cleaved between the amino acid positions 184 and 185 at the Kex2 cleavage site present in the native pro-protein sequence. The pH optimum of Tc-LysN was determined to be 5.0 while it maintained ≥60% activity between pH values 4.5—7.5 and ≥30% activity between pH values 8.5—10.0, indicating its broad applicability. The temperature maximum of Tc-LysN was determined to be 60 °C. After 18 h of incubation at 80 °C, Tc-LysN still retained ~20% activity. Organic solvents such as methanol and acetonitrile, at concentrations as high as 40% (v/v), were found to enhance Tc-LysN’s activity up to ~100% and ~50%, respectively. Tc-LysN’s thermostability, ability to withstand up to 8 M urea, tolerance to high concentrations of organic solvents, and an acidic pH optimum make it a viable candidate to be employed in proteomics workflows in which alkaline conditions might pose a challenge. The nano-LC-MS/MS analysis revealed bovine serum albumin (BSA)’s sequence coverage of 84% using Tc-LysN which was comparable to the sequence coverage of 90% by trypsin peptides.
Analysing and predicting the advance rate of a tunnel boring machine (TBM) in hard rock is integral to tunnelling project planning and execution. It has been applied in the industry for several decades with varying success. Most prediction models are based on or designed for large-diameter TBMs, and much research has been conducted on related tunnelling projects. However, only a few models incorporate information from projects with an outer diameter smaller than 5 m and no penetration prediction model for pipe jacking machines exists to date. In contrast to large TBMs, small-diameter TBMs and their projects have been considered little in research. In general, they are characterised by distinctive features, including insufficient geotechnical information, sometimes rather short drive lengths, special machine designs and partially concurring lining methods like pipe jacking and segment lining. A database which covers most of the parameters mentioned above has been compiled to investigate the performance of small-diameter TBMs in hard rock. In order to provide sufficient geological and technical variance, this database contains 37 projects with 70 geotechnically homogeneous areas. Besides the technical parameters, important geotechnical data like lithological information, unconfined compressive strength, tensile strength and point load index is included and evaluated. The analysis shows that segment lining TBMs have considerably higher penetration rates in similar geological and technical settings mostly due to their design parameters. Different methodologies for predicting TBM penetration, including state-of-the-art models from the literature as well as newly derived regression and machine learning models, are discussed and deployed for backward modelling of the projects contained in the database. New ranges of application for small-diameter tunnelling in several industry-standard penetration models are presented, and new approaches for the penetration prediction of pipe jacking machines in hard rock are proposed.
This report examines exporters’ challenges and possible solutions for public intervention to promote foreign trade. Based on fieldwork conducted in Georgia, we explore which policy approaches can help to stimulate Georgian exports further. Our outcomes show that exporters face substantial barriers such as navigating complex trade regulations, lack of knowledge about target markets, trade finance gaps, as well as new export promotion programs (EPPs) in competitor countries. Other upper-middle-income countries can learn from our results that exporters can significantly benefit from a comprehensive export promotion strategy combined with an ecosystem-based “team” approach. EPPs related to awareness and capacity building in Georgia should be part of this strategy, focusing on challenges such as a lack of knowledge about trade practices and international business skills. Other EPPs must help to mitigate related market failures, as information gathering is costly, and firms have no incentive to share this information with competitors. Furthermore, targeted marketing support and customer matchmaking can answer Georgian exporters’ challenges, such as lack of market access and low sector visibility. Our results also show that public intervention through financial support and risk mitigation is essential for firms with an international orientation. The high-quality, rich outcomes provide significant value for other upper-middle-income countries by exploring the example of Georgia’s contemporary circumstances in an in-depth manner based on extensive interviews and document analysis. Limitations include that our work primarily relies on qualitative data and further research could involve a quantitative study with a diverse range of sectors.
Photovoltaic-heat pump (PV-HP) combinations with battery and energy management systems are becoming increasingly popular due to their ability to increase the autarchy and utilization of self-generated PV electricity. This trend is driven by the ongoing electrification of the heating sector and the growing disparity between growing electricity costs and reducing feed-in tariffs in Germany. Smart control strategies can be employed to control and optimize the heat pump operation to achieve higher self-consumption of PV electricity. This work presents the evaluation results of a smart-grid ready controlled PV-HP-battery system in a single-family household in Germany, using 1-minute-high-resolution field measurement data. Within 12 months evaluation period, a self-consumption of 43% was determined. The solar fraction of the HP amounts to 36%, enabled also due to higher set temperatures for space heating and domestic hot water production. Accordingly, the SPF decreases by 4.0% the space heating and by 5.7% in the domestic hot water mode. The combined seasonal performance factor for the heat pump system increases from 4.2 to 6.7, when only considering the electricity taken from the grid and disregarding the locally generated electricity supplied from photovoltaic and battery units.
"Ad fontes!"
Francesco Petrarca (1301–1374)
In the beginning, there was an idea: the reconstruction of the first "Iron Hand" of the Franconian imperial knight Götz von Berlichingen (1480–1562). We found that with this historical prosthesis, simple actions for daily use, such as holding a wine glass, a mobile phone, a bicycle handlebar grip, a horse’s reins, or some grapes, are possible without effort. Controlling this passive artificial hand, however, is based on the help of a healthy second hand.
Physical unclonable functions (PUFs) are increasingly generating attention in the field of hardware-based security for the Internet of Things (IoT). A PUF, as its name implies, is a physical element with a special and unique inherent characteristic and can act as the security anchor for authentication and cryptographic applications. Keeping in mind that the PUF outputs are prone to change in the presence of noise and environmental variations, it is critical to derive reliable keys from the PUF and to use the maximum entropy at the same time. In this work, the PUF output positioning (POP) method is proposed, which is a novel method for grouping the PUF outputs in order to maximize the extracted entropy. To achieve this, an offset data is introduced as helper data, which is used to relax the constraints considered for the grouping of PUF outputs, and deriving more entropy, while reducing the secret key error bits. To implement the method, the key enrollment and key generation algorithms are presented. Based on a theoretical analysis of the achieved entropy, it is proven that POP can maximize the achieved entropy, while respecting the constraints induced to guarantee the reliability of the secret key. Moreover, a detailed security analysis is presented, which shows the resilience of the method against cyber-security attacks. The findings of this work are evaluated by applying the method on a hybrid printed PUF, where it can be practically shown that the proposed method outperforms other existing group-based PUF key generation methods.