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The growing threat posed by multidrug-resistant (MDR) pathogens, such as Klebsiella pneumoniae (Kp), represents a significant challenge in modern medicine. Traditional antibiotic therapies are often ineffective against these pathogens, leading to high mortality rates. MDR Kp infections pose a novel challenge in military medical contexts, particularly in Medical Biodefense, as they can be deliberately spread, leading to resource-intensive care in military centres. Recognizing this issue, the European Defence Agency initiated a prioritised research project in 2023 (EDF Resilience PHAGE- SGA 2023). To address this challenge, the Bundeswehr Institute of Microbiology (IMB) leads BMBF- (Federal Ministry of Education and Research) and EU-funded projects on the use of bacteriophages as adjuvant therapy alongside antibiotics. Since 2017, the IMB has isolated and characterised Kp phages, collecting over 600 isolates and optimizing their production for therapy, in compliance with the EMA (European Medicine Agency) guidelines. This involves in vitro phage genome packaging to minimize endotoxin load, reduce manufacturing costs, and shorten production times. The goal of this work was to establish MinION sequencing (Oxford Nanopore Technology) as a quick and reliable way for initial identification and characterisation of phage genomes. Especially as a quick screening method for isolated on Kp, prior to more precise but also more expensive and time consuming sequencing methods like Illumina. This characterisation is crucial for developing a personalized pipeline aimed at producing magistral or Good Manufacturing Practice (GMP) quality medicinal phage solutions tailored individually for each patient. DNA extraction methods were compared to identify suitable input DNA for sequencing purposes. Additionally, the quality of this DNA was as- sessed to determine its suitability for in vitro phage packaging, which was successfully done achieving a phage titer of 103, confirming that the DNA used for MinION sequencing could indeed be used for acellular packaging. The created genomes were annotated and compared with Illumina sequencing, revealing high similarity in all five individually tested cases. Between the generated sequences only a 4% maximal percentual difference in genome size was observed, while simultaneously showing high similarity in the actual sequence. Throughout the course of this study, a total of 645.15 GB of sequencing data were generated. In total, 38 phages were successfully characterised, with 21 phage genomes assembled and annotated, and saved in the IMB database.
Steroid hormones (SHs) are a rising concern due to their high bioactivity, ubiquitous nature, and prolonged existence as a micropollutants in water, they pose a potential risk to both human health and the environment, even at low concentrations. Estrogens, progesterone, and testosterone are the three important types of steroids essential for human development and maintaining multiorgan balance, are focus to this concern. These steroid hormones originate
from various sources, including human and livestock excretions, veterinary medications, agricultural runoff, and pharmaceuticals, contributing to their presence in the environment. According to the recommendation of WHO, the guidance value for estradiol (E2) is 1 ng/L. There are several methods been attempted to remove the SH micropollutant by conventional water and wastewater technologies which are still under research. Among the various methods, electrochemical membrane reactor (EMR) is one of the emerging technologies that can address the challenge of insufficient SHs removal from the aquatic environment by conventional treatment. The degradation of SHs can be significantly influenced by various factors when treated with EMR.
In this project, the removal of SH and the important mechanism for the removal using carbon nanotube CNT-EMR is studied and the efficiency of CNT-EMR in treating the SH micropollutant is identified. By varying different parameters this experiment is carried out with the (PES-CNTs) ultrafiltration membrane. The study is carried out depending upon the SH removal based on the limiting factor such as cell voltage, flux, temperature, concentration, and type of the SH.
Globale Ereignisse politischen, wirtschaftlichen oder kulturellen Ursprungs führen dazu, dass Unternehmen sich gezwungen sehen zu handeln, um wettbewerbsfähig zu bleiben. In vielen Fällen wird dabei so vorgegangen, dass versteckte Preiserhöhungen vollzogen werden. Auch Unternehmen, die mit ihrem Angebot einen gesellschaftlichen Zusatznutzen erbringen, erhöhen die Preise, da nur so der verfolgte ökologische oder soziale Purpose erhalten werden kann, kommunizieren dies jedoch offen und erhöhen dadurch ihre Kundenloyalität. Dieses Vorgehen ist bislang jedoch überwiegend in den USA zu beobachten. Da das Thema Purpose auch in Deutschland immer höhere Relevanz erfährt, stellt sich die Frage der Übertragbarkeit. Die Forschungsfrage lautet deshalb: Inwiefern beeinflusst die Kommunikation von purpose-getriebenen Preissteigerungen das Markenimage von B2C-Unternehmen in Deutschland? Um der Forschungsfrage nachzugehen, wurde ein empirischer Forschungsansatz gewählt, der in Form einer quantitativen Studie umgesetzt wurde, die die Meinung der Studierendenschaft der Gen Z und Y der Hochschule Offenburg abbildet. Die Ergebnisse der Umfrage zeigten, dass die Glaubwürdigkeit und Akzeptanz von purpose-getriebenen Preiserhöhungen vom gegenwärtigen Markenimage bzw. dem übergeordneten Image einer Branche abhängen. Purpose wird eine hohe Bedeutung zugesprochen, die sich jedoch aufgrund der Preissensibilität der Zielgruppe nicht immer in der Markenwahl widerspiegelt. Dies verdeutlicht, dass Purpose das Potenzial besitzt, das Markenimage nachhaltig zu beeinflussen und zu prägen und die Zielgruppe der Gen Z und Y zukünftig an sich zu binden. Ferner wurde deutlich, dass bei der Umsetzung von Purpose bestimmte Kriterien verfolgt werden sollten, die bei der Kommunikation zu berücksichtigen sind, um eine authentische Wirkung zu erzielen.
This thesis focuses on the development and implementation of a Datagram Transport Layer Security (DTLS) communication framework within the ns-3 network simulator, specifically targeting the LoRaWAN model network. The primary aim is to analyse the behaviour and performance of DTLS protocols across different network conditions within a LoRaWAN context. The key aspects of this work include the following.
Utilization of ns-3: This thesis leverages ns-3’s capabilities as a powerful discrete event network simulator. This platform enables the emulation of diverse network environments, characterized by varying levels of latency, packet loss, and bandwidth constraints.
Emulation of Network Challenges: The framework specifically addresses unique challenges posed by certain network configurations, such as duty cycle limitations. These constraints, which limit the time allocated for data transmission by each device, are crucial in understanding the real-world performance of DTLS protocols.
Testing in Multi-client-server Scenarios: A significant feature of this framework is its ability to test DTLS performance in complex scenarios involving multiple clients and servers. This is vital for assessing the behaviour of a protocol under realistic network conditions.
Realistic Environment Simulation: By simulating challenging network conditions, such as congestion, limited bandwidth, and resource constraints, the framework provides a realistic environment for thorough evaluation. This allows for a comprehensive analysis of DTLS in terms of security, performance, and scalability.
Overall, this thesis contributes to a deeper understanding of DTLS protocols by providing a robust tool for their evaluation under various and challenging network conditions.
The progress in machine learning has led to advanced deep neural networks. These networks are widely used in computer vision tasks and safety-critical applications. The automotive industry, in particular, has experienced a significant transformation with the integration of deep learning techniques and neural networks. This integration contributes to the realization of autonomous driving systems. Object detection is a crucial element in autonomous driving. It contributes to vehicular safety and operational efficiency. This technology allows vehicles to perceive and identify their surroundings. It detects objects like pedestrians, vehicles, road signs, and obstacles. Object detection has evolved from being a conceptual necessity to an integral part of advanced driver assistance systems (ADAS) and the foundation of autonomous driving technologies. These advancements enable vehicles to make real-time decisions based on their understanding of the environment, improving safety and driving experiences. However, the increasing reliance on deep neural networks for object detection and autonomous driving has brought attention to potential vulnerabilities within these systems. Recent research has highlighted the susceptibility of these systems to adversarial attacks. Adversarial attacks are well-designed inputs that exploit weaknesses in the deep learning models underlying object detection. Successful attacks can cause misclassifications and critical errors, posing a significant threat to the functionality and safety of autonomous vehicles. With the rapid development of object detection systems, the vulnerability to adversarial attacks has become a major concern. These attacks manipulate inputs to deceive the target system, significantly compromising the reliability and safety of autonomous vehicles. In this study, we focus on analyzing adversarial attacks on state-of-the-art object detection models. We create adversarial examples to test the models’ robustness. We also check if the attacks work on a different object detection model meant for similar tasks. Additionally, we extensively evaluate recent defense mechanisms to see how effective they are in protecting deep neural networks (DNNs) from adversarial attacks and provide a comprehensive overview of the most commonly used defense strategies against adversarial attacks, highlighting how they can be implemented practically in real-world situations.
Privacy is the capacity to keep some things private despite their social repercussions. It relates to a person’s capacity to control the amount, time, and circumstances under which they disclose sensitive personal information, such as a person’s physiology, psychology, or intelligence. In the age of data exploitation, privacy has become even more crucial. Our privacy is now more threatened than it was 20 years ago, outside of science and technology, due to the way data and technology highly used. Both the kinds and amounts of information about us and the methods for tracking and identifying us have grown a lot in recent years. It is a known security concern that human and machine systems face privacy threats. There are various disagreements over privacy and security; every person and group has a unique perspective on how the two are related. Even though 79% of the study’s results showed that legal or compliance issues were more important, 53% of the survey team thought that privacy and security were two separate things. Data security and privacy are interconnected, despite their distinctions. Data security and data privacy are linked with each other; both are necessary for the other to exist. Data may be physically kept anywhere, on our computers or in the cloud, but only humans have authority over it. Machine learning has been used to solve the problem for our easy solution. We are linked to our data. Protect against attackers by protecting data, which also protects privacy. Attackers commonly utilize both mechanical systems and social engineering techniques to enter a target network. The vulnerability of this form of attack rests not only in the technology but also in the human users, making it extremely difficult to fight against. The best option to secure privacy is to combine humans and machines in the form of a Human Firewall and a Machine Firewall. A cryptographic route like Tor is a superior choice for discouraging attackers from trying to access our system and protecting the privacy of our data There is a case study of privacy and security issues in this thesis. The problems and different kinds of attacks on people and machines will then be briefly talked about. We will explain how Human Firewalls and machine learning on the Tor network protect our privacy from attacks such as social engineering and attacks on mechanical systems. As a real-world test, we will use genomic data to try out a privacy attack called the Membership Inference Attack (MIA). We’ll show Machine Firewall as a way to protect ourselves, and then we’ll use Differential Privacy (DP), which has already been done. We applied the method of Lasso and convolutional neural networks (CNN), which are both popular machine learning models, as the target models. Our findings demonstrate a logarithmic link between the desired model accuracy and the privacy budget.
This study investigates the impact of global payroll outsourcing on organizational efficiency and cost reduction based on the analysis of diverse implications stemming from thirty one (31) survey results. The findings reveal multifaceted challenges and benefitsassociated with outsourcing global payroll processing.
The research also unveils the most benefits of global payroll outsourcing. Notably, there's a consensus on the reduction in time-to-process payroll, cost per payroll processed, and improved payroll accuracy rate. Outsourcing streamlines processes, enhances operational efficiency, and contributes to faster, more accurate financial reporting.
Despite these benefits and challenges, statistical analysis reveals weak correlations between outsourcing global payroll and cost reduction or improved efficiency in various parameters, indicating a lack of a significant relationship. Consequently, the results, suggest no substantial correlation between global payroll outsourcing and enhanced efficiency or cost reduction based on this study's data.
Decarbonisation Strategies in Energy Systems Modelling: APV and e-tractors as Flexibility Assets
(2023)
This work presents an analysis of the impact of introducing Agrophotovoltaic technologies and electric tractors into Germany’s energy system. Agrophotovoltaics involves installing photovoltaic systems in agricultural areas, allowing for dual usage of the land for both energy generation and food production. Electric tractors, which are agricultural machinery powered by electric motors, can also function as energy storage units, providing flexibility to the grid. The analysis includes a sensitivity study to understand how the availability of agricultural land influences Agrophotovoltaic investments, followed by the examination of various scenarios that involve converting diesel tractors to electric tractors. These scenarios are based on the current CO2 emission reduction targets set by the German Government, aiming for a 65% reduction below 1990 levels by 2030 and achieving zero emissions by 2045. The results indicate that approximately 3% of available agricultural land is necessary to establish a viable energy mix in Germany. Furthermore, the expansion of electric tractors tends to reduce the overall system costs and enhances the energy-cost-efficiency of Agrophotovoltaic investments.
In the past ten years, applications of artificial neural networks have changed dramatically. outperforming earlier predictions in domains like robotics, computer vision, natural language processing, healthcare, and finance. Future research and advancements in CNN architectures, Algorithms and applications are expected to revolutionize various industries and daily life further. Our task is to find current products that resemble the given product image and description. Deep learning-based automatic product identification is a multi-step process that starts with data collection and continues with model training, deployment, and continuous improvement. The caliber and variety of the dataset, the design selected, and ongoing testing and improvement all affect the model's effectiveness. We achieved 81.47% training accuracy and 72.43% validation accuracy for our combined text and image classification model. Additionally, we have discussed the outcomes from the other dataset and numerous methods for creating an appropriate model.