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BACKGROUND:
While hearing aids for a contralateral routing of signals (CROS-HA) and bone conduction devices have been the traditional treatment for single-sided deafness (SSD) and asymmetric hearing loss (AHL), in recent years, cochlear implants (CIs) have increasingly become a viable treatment choice, particularly in countries where regulatory approval and reimbursement schemes are in place. Part of the reason for this shift is that the CI is the only device capable of restoring bilateral input to the auditory system and hence of possibly reinstating binaural hearing. Although several studies have independently shown that the CI is a safe and effective treatment for SSD and AHL, clinical outcome measures in those studies and across CI centers vary greatly. Only with a consistent use of defined and agreed-upon outcome measures across centers can high-level evidence be generated to assess the safety and efficacy of CIs and alternative treatments in recipients with SSD and AHL.
METHODS:
This paper presents a comparative study design and minimum outcome measures for the assessment of current treatment options in patients with SSD/AHL. The protocol was developed, discussed, and eventually agreed upon by expert panels that convened at the 2015 APSCI conference in Beijing, China, and at the CI 2016 conference in Toronto, Canada.
RESULTS:
A longitudinal study design comparing CROS-HA, BCD, and CI treatments is proposed. The recommended outcome measures include (1) speech in noise testing, using the same set of 3 spatial configurations to compare binaural benefits such as summation, squelch, and head shadow across devices; (2) localization testing, using stimuli that rove in both level and spectral content; (3) questionnaires to collect quality of life measures and the frequency of device use; and (4) questionnaires for assessing the impact of tinnitus before and after treatment, if applicable.
CONCLUSION:
A protocol for the assessment of treatment options and outcomes in recipients with SSD and AHL is presented. The proposed set of minimum outcome measures aims at harmonizing assessment methods across centers and thus at generating a growing body of high-level evidence for those treatment options.
The effect of fluctuating maskers on speech understanding of high-performing cochlear implant users
(2016)
Objective: The present study evaluated whether the poorer baseline performance of cochlear implant (CI) users or the technical and/or physiological properties of CI stimulation are responsible for the absence of masking release. Design: This study measured speech reception thresholds (SRTs) in continuous and modulated noise as a function of signal to noise ratio (SNR). Study sample: A total of 24 subjects participated: 12 normal-hearing (NH) listeners and 12 subjects provided with recent MED-EL CI systems. Results: The mean SRT of CI users in continuous noise was −3.0 ± 1.5 dB SNR (mean ± SEM), while the normal-hearing group reached −5.9 ± 0.8 dB SNR. In modulated noise, the difference across groups increased considerably. For CI users, the mean SRT worsened to −1.4 ± 2.3 dB SNR, while it improved for normal-hearing listeners to −18.9 ± 3.8 dB SNR. Conclusions: The detrimental effect of fluctuating maskers on SRTs in CI users shown by prior studies was confirmed by the current study. Concluding, the absence of masking release is mainly caused by the technical and/or physiological properties of CI stimulation, not just the poorer baseline performance of many CI users compared to normal-hearing subjects. Speech understanding in modulated noise was more robust in CI users who had a relatively large electrical dynamic range.
Covert channels have been known for a long time because of their versatile forms of appearance. For nearly every technical improvement or change in technology, such channels have been (re-)created or known methods have been adapted. For example, the introduction of hyperthreading technology has introduced new possibilities for covert communication between malicious processes because they can now share the arithmetic logical unit as well as the L1 and L2 caches, which enable establishing multiple covert channels. Even virtualization, which is known for its isolation of multiple machines, is prone to covert- and side-channel attacks because of the sharing of resources. Therefore, it is not surprising that cloud computing is not immune to this kind of attacks. Moreover, cloud computing with multiple, possibly competing users or customers using the same shared resources may elevate the risk of illegitimate communication. In such a setting, the “air gap” between physical servers and networks disappears, and only the means of isolation and virtual separation serve as a barrier between adversary and victim. In the work at hand, we will provide a survey on vulnerable spots that an adversary could exploit trying to exfiltrate private data from target virtual machines through covert channels in a cloud environment. We will evaluate the feasibility of example attacks and point out proposed mitigation solutions in case they exist.
Structured Innovation with TRIZ in Science and Industry - Creating Value for Customers and Society
(2016)
Serendipities in der Medizin
(2016)
Zufälle begleiten unser Leben. Auch bei wichtigen Entdeckungen und Entwicklungen in der Medizin spielt der „Zufall“ (engl. „serendipity“) eine Rolle. Hierzu gehören u. a. die Mendelschen Gesetze, die Ermittlung der menschlichen Chromosomenzahl, die Entdeckung der DNS durch Watson und Crick, der PAP-Test oder die Entdeckung der Röntgenstrahlung und der Radioaktivität. Aber auch und gerade in der Pharmakologie gibt es viele Beispiele für Serendipitäten. Einige gehen eng mit Zufällen bei der Entdeckung der Bakteriologie einher.
Selective separation of CO2-CH4 mixed gases via magnesium aminoethylphosphonate nanoparticles
(2016)
We present a novel scheme for Slotted ALOHA random access systems that combines physical-layer network coding (PLNC) with multiuser detection (MUD). The PLNC and MUD are applied jointly at the physical layer to be able to extract any linear combination of messages experiencing a collision within a slot. The set of combinations extracted from a whole frame is then processed by the receiver to recover the original packets. A simple precoding stage at the transmitting terminals allows the receiver to further decrease the packet loss rate. We present results for the decoding at the physical layer as well as several performance measures at frame level, namely, throughput, packet loss rate, and energy efficiency. The results we present are promising and suggest that a cross-layer approach leveraging on the joint use of PLNC and MUD can significantly improve the performance of random access systems in the presence of slow fading.
Der Beitrag behandelt ausgewählte Themenkomplexe im Zusammenhang mit der Vorspannung von Schraubenverbindungen im Stahlbau. Es werden verschiedene Anwendungen und damit verbundene Aspekte beleuchtet und diskutiert, zum Beispiel die Schraubensicherung durch Vorspannung oder die Steifigkeit der Verbindung. Dem vorangestellt ist eine kurze Einführung in die mechanische Wirkung der Vorspannung in der Verbindung sowie eine Vorstellung der Vorspannverfahren.
In recent years simple CAD systems have entered the market, which are offered as freeware or open source projects. These systems prove to be a key technology especially for the further expansion of 3D printing, because a 3D model of the object to be printed is a prerequisite for the use of a 3D printer. Therefore, this contribution reviews several common simple CAD systems. Thus technical and economic criteria are evaluated. It is also demonstrated how the models designed in this manner can be used in 3D printing. A case study shows the possibilities and limitations to be expected when using simple CAD systems.
Physics-based Modeling of the Electric Arc furnace Process using Object-Oriented Language Modelica
(2016)
Electric arc furnaces (EAF) are complex industrial plants whose actual behavior depends upon numerous factors. Due to its energy intensive operation, the EAF process has always been subject to optimization efforts. For these reasons, several models have been proposed in literature to analyze and predict different modes of operation. Most of these models focused on the processes inside the vessel itself. The present paper introduces a dynamic, physics-based model of a complete EAF plant which consists of the four subsystems vessel, electric system, electrode regulation, and off-gas system. Furthermore the solid phase is not treated to be homogenous but a simple spatial discretization is employed. Hence it is possible to simulate the energy input by electric arcs and fossil fuel burners depending on the state of the melting progress. The model is implemented in object-oriented, equation-based language Modelica. The simulation results are compared to literature data.
Electric arc furnaces (EAF) are complex industrial plants whose actual behavior depends upon numerous factors. Due to its energy intensive operation, the EAF process has always been subject to optimization efforts. For these reasons, several models have been proposed in literature to analyze and predict different modes of operation. Most of these models focused on the processes inside the vessel itself. The present paper introduces a dynamic, physics-based model of a complete EAF plant which consists of the four subsystems vessel, electric system, electrode regulation, and off-gas system. Furthermore the solid phase is not treated to be homogenous but a simple spatial discretization is employed. Hence it is possible to simulate the energy input by electric arcs and fossil fuel burners depending on the state of the melting progress. The model is implemented in object-oriented, equation-based language Modelica. The simulation results are compared to literature data.
Proton Exchange Membrane Fuel Cells (PEMFC) are energy efficient and environmentally friendly alternatives to conventional energy conversion systems in many yet emerging applications. In order to enable prediction of their performance and durability, it is crucial to gain a deeper understanding of the relevant operation phenomena, e.g., electrochemistry, transport phenomena, thermodynamics as well as the mechanisms leading to the degradation of cell components. Achieving the goal of providing predictive tools to model PEMFC performance, durability and degradation is a challenging task requiring the development of detailed and realistic models reaching from the atomic/molecular scale over the meso scale of structures and materials up to components, stack and system level. In addition an appropriate way of coupling the different scales is required.
This review provides a comprehensive overview of the state of the art in modeling of PEMFC, covering all relevant scales from atomistic up to system level as well as the coupling between these scales. Furthermore, it focuses on the modeling of PEMFC degradation mechanisms and on the coupling between performance and degradation models.
The ability to detect a target signal masked by noise is improved in normal-hearing listeners when interaural phase differences (IPDs) between the ear signals exist either in the masker or in the signal. To improve binaural hearing in bilaterally implanted cochlear implant (BiCI) users, a coding strategy providing the best possible access to IPD is highly desirable. In this study, we compared two coding strategies in BiCI users provided with CI systems from MED-EL (Innsbruck, Austria). The CI systems were bilaterally programmed either with the fine structure processing strategy FS4 or with the constant rate strategy high definition continuous interleaved sampling (HDCIS). Familiarization periods between 6 and 12 weeks were considered. The effect of IPD was measured in two types of experiments: (a) IPD detection thresholds with tonal signals addressing mainly one apical interaural electrode pair and (b) with speech in noise in terms of binaural speech intelligibility level differences (BILD) addressing multiple electrodes bilaterally. The results in (a) showed improved IPD detection thresholds with FS4 compared with HDCIS in four out of the seven BiCI users. In contrast, 12 BiCI users in (b) showed similar BILD with FS4 (0.6 ± 1.9 dB) and HDCIS (0.5 ± 2.0 dB). However, no correlation between results in (a) and (b) both obtained with FS4 was found. In conclusion, the degree of IPD sensitivity determined on an apical interaural electrode pair was not an indicator for BILD based on bilateral multielectrode stimulation.
Two closely related series of paddle-wheel-based triazolyl isophthalate MOFs are presented. Thermal and CO2 adsorption studies reveal network flexibility induced by alkyl substituents of the linker. By choice of the substituent, the pore volumes and pore diameters can be adjusted. Fine-tuning of the gate opening pressure and the hysteresis shape is possible by modulating the substitution pattern and by choice of the metal ion.
Optimal microgrid scheduling with peak load reduction involving an electrolyzer and flexible loads
(2016)
This work consists of a multi-objective mixed-integer linear programming model for defining optimized schedules of components in a grid-connected microgrid. The microgrid includes a hydrogen energy system consisting of an alkaline electrolyzer, hydrogen cylinder bundles and a fuel cell for energy storage. Local generation is provided from photovoltaic panels, and the load is given by a fixed load profile combined with a flexible electrical load, which is a battery electric vehicle. The electrolyzer has ramp-up constraints which are modeled explicitly. The objective function includes, besides operational costs and an environmental indicator, a representation of peak power costs, thus leading to an overall peak load reduction under optimized operation. The model is used both for controlling a microgrid in a field trial set-up deployed in South-West Germany and for simulating the microgrid operation for defined period, thus allowing for economic system evaluation. Results from defined sample runs show that the energy storage is primarily used for trimming the peak of electricity drawn from the public grid and is not solely operated with excess power. The flexible demand operation also helps keeping the peak at its possible minimum.
The existence of acoustic waves with displacements localized at the tip of an isotropic elastic wedge was rigorously proven by Kamotskii, Zavorokhin and Nazarov. This proof, which is based on a variational approach, is extended to rectangular anisotropic wedges. For two high-symmetry configurations of rectangular edges in elastic media with tetragonal symmetry, a criterion is derived that allows identifying the boundary between the regions of existence for wedge modes of even and odd symmetry in regions of parameter space, where even- and odd-symmetry modes do not exist simultaneously. Furthermore, rectangular edges with non-equivalent surfaces are analyzed, and it is shown that at rectangular edges of cubic elastic media with one (110) surface and one (001) surface, a tip-localized guided wave always exists, apart from special cases that are characterized.