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- cardiac contractility modulation (1) (remove)
Cardiac contractility modulation (CCM) is a
device-
based therapy for the treatment of systolic left
ventricular chronic heart failure. Unlike other device
-
based therapies for heart failure, CCM delivers non
-
excitatory pacing signals to the myocardium. This leads to
an extension of the action potential and to an improved
contractility of the heart. The modeling and simulation
was done with the electromagnetic simulation software
CST. Three CCM electrodes were inserted into the
Offenburg heart rhythm model an
d subsequently
simulated the electric field propagation in CCM therapy.
In addition, simulations of CCM have been performed
with electrodes from other device
-based therapies, such as
cardiac resynchronization therapy (CRT) and implantable
cardioverter.
/. defi
brillator (ICD) therapy.
At the same
distance to the simulation electrode, the electric field is
slightly stronger in CCM therapy than in CCM therapy
with additionally implanted CRT or ICD electrodes. In
addition, there is a change in the electric field pr
opagation
at the electrodes of the CRT and the shock electrode of the
ICD.
By simulating several different therapy procedures
on the heart, it is possible to check how they affect their
behavior during normal operation. CCM heart rhythm
model simulation al
lows the evaluation the individual
electrical pacing and sensing field during CCM.