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In-vivo and in-vitro comparison of implant-based CRT optimization - What provide new algorithms?
(2011)
Introduction: In cardiac resynchronization therapy (CRT), individual AV delay (AVD) optimization can effectively increase hemodynamics and reduce non-responder rate. Accurate, automatic and easily comprehensible algorithms for the follow-up are desirable. QuickOpt is the first attempt of a semi-automatic intracardiac electrogram (IEGM) based AVD algorithm. We aimed to compare its accuracy and usefulness by in-vitro and in-vivo studies.
Methods: Using the programmable ARSI-4 four-chamber heart rhythm and IEGM simulator (HKP, Germany), the QuickOpt feature of an Epic HF system (St. Jude, USA) was tested in-vitro by simulated atrial IEGM amplitudes between 0.3 and 3.5mV during both, manual and automatic atrial sensing between 0.2 and 1.0mV. Subsequently, in 21 heart failure patients with implanted biventricular defibrillators, QuickOpt was performed in-vivo. Results of the algorithm for VDD and DDD stimulation were compared with echo AV delay optimization.
Results: In-vitro simulations demonstrated a QuickOpt measuring accuracy of ± 8ms. Depending on atrial IEGM amplitude, the algorithm proposed optimal AVD between 90 and 150ms for VDD and between 140 and 200ms for DDD operation, respectively. In-vivo, QuickOpt difference between individual AVD in DDD and VDD mode was either 50ms (20pts) or 40ms (1pt). QuickOpt and echo AVD differed by 41 ± 25ms (7 – 90ms) in VDD and by 18 ± 24ms (17-50ms) in DDD operation. Individual echo AVD difference between both modes was 73 ± 20ms (30-100ms).
Conclusion: The study demonstrates the value of in-vitro studies. It predicted QuickOpt deficiencies regarding IEGM amplitude dependent AVD proposals constrained to fixed individual differences between DDD and VDD mode. Consequently, in-vivo, the algorithm provided AVD of predominantly longer duration than echo in both modes. Accepting echo individualization as gold standard, QuickOpt should not be used alone to optimize AVD in CRT patients.
Introduction: To simplify AV delay (AVD) optimization in cardiac resynchronization therapy (CRT), we reported that the hemodynamically optimal AVD for VDD and DDD mode CRT pacing can be approximated by individually measuring implant-related interatrial conduction intervals (IACT) in oesophageal electrogram (LAE) and adding about 50ms. The programmer-based St Jude QuickOpt algorithm is utilizing this finding. By automatically measuring IACT in VDD operation, it predicts the sensed AVD by adding either 30ms or 60ms. Paced AVD is strictly 50ms longer than sensed AVD. As consequence of those variations, several studies identified distinct inaccuracies of QuickOpt. Therefore, we aimed to seek for better approaches to automate AVD optimization.
Methods: In a study of 35 heart failure patients (27m, 8f, age: 67±8y) with Insync III Marquis CRT-D systems we recorded telemetric electrograms between left ventricular electrode and superior vena cava shock coil (LVtip/SVC = LVCE) simultaneously with LAE. By LVCE we measured intervals As-Pe in VDD and Ap-Pe in DDD operation between right atrial sense-event (As) or atrial stimulus (Ap), resp., and end of the atrial activity (Pe). As-Pe and Ap-Pe were compared with As-LA an Ap-LA in LAE, respectively.
Results: End of the left atrial activity in LVCE could clearly be recognized in 35/35 patients in VDD and 29/35 patients in DDD operation. We found mean intervals As-LA of 40.2±24.5ms and Ap-LA of 124.3±20.6ms. As-Pe was 94.8±24.1ms and Ap-Pe was 181.1±17.8ms. Analyzing the sums of As-LA + 50ms with duration of As-Pe and Ap-LA + 50ms with duration of Ap-Pe, the differences were 4.7±9.2ms and 4.2±8.6ms, resp., only. Thus, hemodynamically optimal timing of the ventricular stimulus can be triggered by automatically detecting Pe in LVCE.
Conclusion: Based on minimal deviations between LAE and LVCE approach, we proposed companies to utilize the LVCE in order to automate individual AVD optimization in CRT pacing.
Vorgestellt wird ein Konzept zur biologischen Methanisierung von Wasserstoff direkt in Biogasreaktoren, mit dem durch Membranbegasung der Methangehalt des Biogases auf > 96 % erhöht werden kann. Essentiell zum Erreichen solch hoher Methanwerte sind die Einhaltung eines optimalen pH-Bereichs und die Vermeidung von H2-Akkumulation. Im Falle einer Limitierung der Methanbildungsrate durch den eigentlichen anaeroben Abbauprozess der Biomasse ist auch eine externe Zufuhr von CO2 zur weiteren Methanbildung denkbar. Das Verfahren soll weiter optimiert und in einem von der Deutschen Bundesstiftung Umwelt geförderten Projekt in der Biogasanlage einer regionalen Käserei in der Praxis getestet werden. Die hier angestrebte Kombination aus dezentraler Abfallverwertung und Eigenenergieerzeugung eines lebensmittelverarbeitenden Betriebs unter Einbindung in ein intelligentes Erneuerbare Energien - Konzept soll einen zusätzlichen Mehrwert liefern.
This work discusses several use cases of post-mortem mobile device tracking in which privacy is required e.g. due to client-confidentiality agreements and sensibility of data from government agencies as well as mobile telecommunication providers. We argue that our proposed Bloomfilter based privacy approach is a valuable technical building block for the arising General Data Protection Regulation (GDPR) requirements in this area. In short, we apply a solution based on the Bloom filters data structure that allows a 3rd party to performsome privacy saving setrelations on a mobiletelco’s access logfile or other mobile access logfile from harvesting parties without revealing any other mobile users in the proximity of a mobile base station but still allowing to track perpetrators.
Printed electronics (PE) is a fast growing technology with promising applications in wearables, smart sensors and smart cards since it provides mechanical flexibility, low-cost, on-demand and customizable fabrication. To secure the operation of these applications, True Random Number Generators (TRNGs) are required to generate unpredictable bits for cryptographic functions and padding. However, since the additive fabrication process of PE circuits results in high intrinsic variation due to the random dispersion of the printed inks on the substrate, constructing a printed TRNG is challenging. In this paper, we exploit the additive customizable fabrication feature of inkjet printing to design a TRNG based on electrolyte-gated field effect transistors (EGFETs). The proposed memory-based TRNG circuit can operate at low voltages (≤ 1 V ), it is hence suitable for low-power applications. We also propose a flow which tunes the printed resistors of the TRNG circuit to mitigate the overall process variation of the TRNG so that the generated bits are mostly based on the random noise in the circuit, providing a true random behaviour. The results show that the overall process variation of the TRNGs is mitigated by 110 times, and the simulated TRNGs pass the National Institute of Standards and Technology Statistical Test Suite.
Printed Electronics is perceived to have a major impact in the fields of smart sensors, Internet of Things and wearables. Especially low power printed technologies such as electrolyte gated field effect transistors (EGFETs) using solution-processed inorganic materials and inkjet printing are very promising in such application domains. In this paper, we discuss a modeling approach to describe the variations of printed devices. Incorporating these models and design flows into our previously developed printed design system allows for robust circuit design. Additionally, we propose a reliability-aware routing solution for printed electronics technology based on the technology constraints in printing crossovers. The proposed methodology was validated on multiple benchmark circuits and can be easily integrated with the design automation tools-set.
Radio frequency identification (RFID) antennas are popular for high frequency (HF) RFID, energy transfer and near field communication (NFC) applications. Particularly for wireless measurement systems the RFID/NFC technology is a good option to implement a wireless communication interface. In this context, the design of corresponding reader and transmitter antennas plays a major role for achieving suitable transmission quality. This work proves the feasibility of the rapid prototyping of a RFID/NFC antenna, which is used for the wireless communication and energy harvesting at the required frequency of 13.56 MHz. A novel and low-cost direct ink writing (DIW) technology utilizing highly viscous silver nanoparticle ink is used for this process. This paper describes the development and analysis of low-cost printed flexible RFID/NFC antennas on cost-effective substrates for a microelectronic vital parameter measurement system. Furthermore, we compare the measured technical parameters with existing copper-based counterparts on a FR4 substrate.
Smart Home or Smart Building applications are a growing market. An increasing challenge is to design energy efficient Smart Home applications to achieve sustainable and green homes. Using the example of the development of an Indoor Smart Gardening system with wireless monitoring and automated watering this paper is discussing in particular the design issue of energy autonomous working sensors and actuators for home automation. Most important part of the presented Smart Gardening system is a 3D printed smart flower pot for single plants. The smart flower pot has integrated a water reservoir for automated plant irrigation and an electronic for monitoring important plant parameters and the water level of the water reservoir. Energy harvesting with solar cells enables energy autonomous working of the flower pot. A low-power wireless interface also integrated in the flowerpot and an external gateway based on a Raspberry Pi 3 enables wireless networking of multiple of those flower pots. The gateway is used for evaluating the plant parameters and as a user interface. Particularly the architecture of the energy autonomous wireless flower pot will be considered, because fully energy autonomous sensors and actuators for home automation could not be implemented without special concepts for the energy supply and the overall electronic.
Process engineering industries are now facing growing economic pressure and societies' demands to improve their production technologies and equipment, making them more efficient and environmentally friendly. However unexpected additional technical and ecological drawbacks may appear as negative side effects of the new environmentally-friendly technologies. Thus, in their efforts to intensify upstream and downstream processes, industrial companies require a systematic aid to avoid compromising of ecological impact. The paper conceptualises a comprehensive approach for eco-innovation and eco- design in process engineering. The approach combines the advantages of Process Intensification as Knowledge-Based Engineering (KBE), inventive tools of Knowledge-Based Innovation (KBI), and main principles and best-practices of Eco-Design and Sustainable Manufacturing. It includes a correlation matrix for identification of eco-engineering contradictions and a process mapping technique for problem definition, database of Process Intensification methods and equipment, as well as a set of strongest inventive operators for eco-ideation.
As engineering graduates and specialists frequently lack the advanced skills and knowledge required to run eco-innovation systematically, the paper proposes a new teaching method and appropriate learning materials in the field of eco-innovation and evaluates the learning experience and outcomes. This programme is aimed at strengthening student’s skills and motivation to identify and creatively overcome secondary eco-contradictions in case if additional environmental problems appears as negative side effects of eco-friendly solutions.
Based on a literature analysis and own investigations, authors propose to introduce a manageable number of eco-innovation tools into a standard one-semester design course in process engineering with particular focus on the identification of eco-problems in existing technologies, selection of the appropriate new process intensification technologies (knowledge-based engineering), and systematic ideation and problem solving (knowledge-based innovation and invention).
The proposed educational approach equips students with the advanced knowledge, skills and competences in the field of eco-innovation. Analysis of the student’s work allows one to recommend simple-to-use tools for a fast application in process engineering, such as process mapping, database of eco-friendly process intensification technologies, and up to 20 strongest inventive operators for solving of environmental problems. For the majority of students in the survey, even the small workload has strengthened their self-confidence and skills in eco-innovation
Growing demands for cleaner production and higher eco-efficiency in process engineering require a comprehensive analysis of technical and environmental outcomes of customers and society. Moreover, unexpected additional technical or ecological drawbacks may appear as negative side effects of new environ-mentally friendly technologies. The paper conceptualizes a comprehensive ap-proach for analysis and ranking of engineering and ecological requirements in process engineering in order to anticipate secondary problems in eco-design and to avoid compromising the environmental or technological goals. For this purpose, the paper presents a method based on integration of the Quality Func-tion Deployment approach with the Importance-Satisfaction Analysis for the requirements ranking. The proposed method identifies and classifies compre-hensively the potential engineering and eco-engineering contradictions through analysis of correlations within requirements groups such as stakehold-er requirements (SRs) and technical requirements (TRs), and additionally through cross-relationship between SRs and TRs.
The 40 Altshuller Inventive Principles with numerous sub-principles remain over decades the most frequently applied tool of the Theory of Inventive Problem Solving TRIZ for systematic idea generation. However, their application often requires a concentrated, creative and abstract way of thinking that can be fairly challenging for the newcomers to TRIZ. This paper describes an approach to reduce the abstraction level of inventive sub-principles and presents the results of the idea generation experiment conducted with three groups of undergraduate and graduate students from different years of study in mechanical and process engineering. The students were asked to generate and to record their individual ideas for three design problems using a pre-defined set of classical and modified sub-principles within 10 minutes. The overall outcomes of the experiment support the assumption that the less abstract wording of the modified sub-principles leads to higher number of ideas. The distribution of ideas between the fields of MATCHEM-IBD (Mechanical, Acoustic, Thermal, Chemical, Electrical, Magnetic, Intermolecular, Biological and Data processing) differs significantly between groups using modified and abstract sub-principles.
Recent deep learning based approaches have shown remarkable success on object segmentation tasks. However, there is still room for further improvement. Inspired by generative adversarial networks, we present a generic end-to-end adversarial approach, which can be combined with a wide range of existing semantic segmentation networks to improve their segmentation performance. The key element of our method is to replace the commonly used binary adversarial loss with a high resolution pixel-wise loss. In addition, we train our generator employing stochastic weight averaging fashion, which further enhances the predicted output label maps leading to state-of-the-art results. We show, that this combination of pixel-wise adversarial training and weight averaging leads to significant and consistent gains in segmentation performance, compared to the baseline models.
Current training methods for deep neural networks boil down to very high dimensional and non-convex optimization problems which are usually solved by a wide range of stochastic gradient descent methods. While these approaches tend to work in practice, there are still many gaps in the theoretical understanding of key aspects like convergence and generalization guarantees, which are induced by the properties of the optimization surface (loss landscape). In order to gain deeper insights, a number of recent publications proposed methods to visualize and analyze the otimization surfaces. However, the computational cost of these methods are very high, making it hardly possible to use them on larger networks. In this paper, we present the GradVis Toolbox, an open source library for efficient and scalable visualization and analysis of deep neural network loss landscapes in Tesorflow and PyTorch. Introducing more efficient mathematical formulations and a novel parallelization scheme, GradVis allows to plot 2d and 3d projections of optimization surfaces and trajectories, as well as high resolution second order gradient information for large networks.
Most machine learning methods require careful selection of hyper-parameters in order to train a high performing model with good generalization abilities. Hence, several automatic selection algorithms have been introduced to overcome tedious manual (try and error) tuning of these parameters. Due to its very high sample efficiency, Bayesian Optimization over a Gaussian Processes modeling of the parameter space has become the method of choice. Unfortunately, this approach suffers from a cubic compute complexity due to underlying Cholesky factorization, which makes it very hard to be scaled beyond a small number of sampling steps. In this paper, we present a novel, highly accurate approximation of the underlying Gaussian Process. Reducing its computational complexity from cubic to quadratic allows an efficient strong scaling of Bayesian Optimization while outperforming the previous approach regarding optimization accuracy. First experiments show speedups of a factor of 162 in single node and further speed up by a factor of 5 in a parallel environment.
One of the challenges for autonomous driving in general is to detect objects in the car's camera images. In the Audi Autonomous Driving Cup (AADC), among those objects are other cars, adult and child pedestrians and emergency vehicle lighting. We show that with recent deep learning networks we are able to detect these objects reliably on the limited Hardware of the model cars. Also, the same deep network is used to detect road features like mid lines, stop lines and even complete crossings. Best results are achieved using Faster R-CNN with Inception v2 showing an overall accuracy of 0.84 at 7 Hz.
This paper describes the concept and some results of the project "Menschen Lernen Maschinelles Lernen" (Humans Learn Machine Learning, ML2) of the University of Applied Sciences Offenburg. It brings together students of different courses of study and practitioners from companies on the subject of Machine Learning. A mixture of blended learning and practical projects ensures a tight coupling of machine learning theory and application. The paper details the phases of ML2 and mentions two successful example projects.
The high peak power in comparison to the average transmit power is one of the major long-standing problems in multicarrier modulation and is known as the PAPR (peak to average power ratio) problem. Many PAPR reduction methods have been devised and their comparison is usually based on the complementary cumulative distribution function (CCDF) of the PAPR. While this comparison is straightforward and easy to compute, its relationship with system performance metrics like the (uncoded) BER or the word error rate (WER) for coded systems is considerably more involved. We evaluate the impact of the PAPR on performance metrics like uncoded BER, EVM (error vector magnitude), mutual information and the WER for soft decoding. In this context, we find that system performance is not necessarily degraded by an increasing PAPR. We show that a high number of subcarriers, despite the corresponding high PAPR, is actually not a problem for the system performance and provide a simple explanation for this seemingly counter-intuitive fact.
Classification of TRIZ Inventive Principles and Sub-Principles for Process Engineering Problems
(2019)
The paper proposes a classification approach of 40 Inventive Principles with an extended set of 160 sub-principles for process engineering, based on a thorough analysis of 155 process intensification technologies, 200 patent documents, 6 industrial case studies applying TRIZ, and other sources. The authors define problem-specific sub-principles groups as a more precise and productive ideation technique, adaptable for a large diversity of problem situations, and finally, examine the anticipated variety of ideation using 160 sub-principles with the help of MATCEM-IBD fields.
Kleinstlebewesen vorgestellt, das Vitalparameter erfasst und diese in einem FRAM-Speicher bis zum Auslesen abspeichert. Durch eine drahtlose RFID-/NFC-Ausleseschnittstelle kann die erfasste Körpertemperatur und der Puls der letzten Wochen ausgelesen werden. Alle Einstellungen des Messsystems können durch einen geeigneten RFID-Reader für Laptops oder durch Smartphones über die NFC-Schnittstelle geändert werden. Das vollständige Aufladen des nur 3 g leichten und 15 mm x 25 mm großen Messsystems erfolgt durch eine selbstgedruckte RFID-Reader-Antenne in Verbindung mit einem RFID-Reader und benötigt hierzu weniger als 21 Stunden. Bei vollständig aufgeladenem Energiespeicher ist ein Betrieb von 47 Tagen möglich. Dies wird durch ein speziell für das Messsystem konzipiertes Lade- und Powermanagement erreicht. Neben der Auswahl von energiesparenden Komponenten für die Hardware und deren bestmöglichen Nutzung, wurde die Software so optimiert, dass das Programm schnell und stromsparend abgearbeitet wird. Die Erweiterbarkeit und Anpassung wird durch das modulare Konzept auch in anderen Bereichen gewährleistet.