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Narrowband Internet-of-Things (NB-IoT) is a 3rd generation partnership project (3GPP) standardized cellular technology, adopted for 5G and optimized for massive Machine Type Communication (mMTC). Applications are anticipated around infrastructure monitoring, asset management, smart city and smart energy applications. In this paper, we evaluate the suitability of NB-IoT for private (campus) networks in industrial environments, including complex cloud-based applications around process automation. An end-to-end system has been developed, comprising of a sensor unit connected to a NB-IoT modem, a base station (gNodeB) equipped with a beamforming array and a local (private) network architecture comprising a sensor management system in the edge cloud. The experimental study includes field tests in realistic industrial environments with latency, reliability and coverage measurements. The results show a good suitability of NB-IoT for process automation with high scalability, low-power requirements and moderate latency requirements.
The purpose of this study was to describe the effects of running speed and slope on metatarsophalangeal (MTP) joint kinematics. 22 male and female runners underwent 3D motion analysis on an instrumented treadmill at three different speeds (2.5 m/s, 3.0 m/s, 3.5 m/s). At each speed, participants ran at seven slope conditions (downhill: -15%, -10%, -5%, level, and uphill: +5%, +10%, +15%). We found a significant main effect (p < 0.001) of running speed and slope on peak MTP dorsiflexion and a running speed by slope interaction effect (p < 0.001) for peak MTP dorsiflexion velocity. These findings highlight the need to consider running intensity and environmental factors like running surface inclination when considering MTP joint mechanics and technological aids to support runners.
Objective: Dickkopf 3 (DKK3) has been identified as a urinary biomarker. Values above 4000 pg/mg creatinine (Cr) were linked with a higher risk of short-term decline of kidney function (J Am Soc Nephrol 29: 2722–2733). However, as of today, there is little experience with DKK3 as a risk marker in everyday clinical practice. We used algorithm-based data analysis to evaluate the potential dependence of DKK3 in a cohort from a large single center in Germany.
Method: DKK3 was measured in all CKD patients in our center October 1 st 2018 till Dec. 31 2019, together with calculated GFR (eGFR) and urinary albumin/creatinine ratio (UACR). Kidney transplant patients were excluded. Until the end of follow-up Dec 31 st 2021, repeated measurements were performed for all parameters. Data analysis was performed using MD-Explorer (BioArtProducts, Rostock, Germany) and Python with multiple libraries. Linear regression models were applied in patients for DKK3, eGFR and UACR. Comparison of the models was performed with a twosided Kolmogorov-Smirnov test.
Results: 1206 DKK3 measurements were performed in 1103 patients (621 male, age 70yrs, eGFR 29,41 ml/min/1.73qm, UACR 800 mg/g). 134 patients died during follow-up. DKK3 mean was 2905 pg/mg Cr (max. 20000, 75 % percentile 3800). 121 pts had DKK3 > 4000. At the end of follow-up 7 % of patients with DKK3 < 4000 (initial eGFR 17.6) versus 39.6 % of patients with DDK3 > 4000 (initial eGFR 15.7) underwent dialysis. Compared to eGFR and UACR at baseline, DKK3 > 4000 performed best to predict eGFR loss over the next 12 months.
Conclusion: In this cohort of CKD patients, DKK3 > 4000 at baseline predicted the eGFR slope better than eGFR or UACR at baseline. DKK3 > 4000 reflected a higher risk of progression towards ESRD in patients with similar baseline eGFR levels.
The conversion of space heating for private households to climate-neutral energy sources is an essential component of the energy transition, as this sector as of 2018 was responsible for 9.4 % of Germany’s carbon dioxide emissions. In addition to reducing demand through better insulation, the use of heat pumps fed with electricity from renewable energy sources, such as on-site photovoltaics (PV) systems, is an important solution approach.
Advanced energy management and control can help to make optimal use of such heating systems. Optimal here can e.g. refer to maximizing self-consumption of self-generated PV power, extended component lifetime or a grid-friendly behavior that avoids load peaks. A powerful method for this is model predictive control (MPC), which calculates optimal schedules for the controllable influence variables based on models of the system dynamics, current measurements of system states and predictions of future external influence parameters.
In this paper, we will discuss three different use cases that show how artificial intelligence can contribute to the realization of such an MPC-based energy management and control system. This will be done using the example of a real inhabited single family home that has provided the necessary data for this purpose and where the methods are implemented and tested. The heating system consists of an air-water heat pump with direct condensation, a thermal stratified storage tank, a pellet burner and a heating rod and provides both heating and hot water. The house generates a significant portion of its electricity needs through a rooftop PV system.
VR-based implementation of interactive laboratory experiments in optics and photonics education
(2022)
Within the framework of a developed blended learning concept, a lot of experience has already been gained with a mixture of theoretical lectures and hands-on activities, combined with the advantages of modern digital media. Here, visualizations using videos, animations and augmented reality have proven to be effective tools to convey learning content in a sustainable way. In the next step, ideas and concepts were developed to implement hands-on laboratory experiments in a virtual environment. The main focus is on the realization of virtual experiments and environments that give the students a deep insight into selected subfields of optics and photonics.
During the coronavirus crisis, labs had to be offered in digital form in mechanical engineering at short notice. For this purpose, digital twins of more complex test benches in the field of fluid energy machines were used in the mechanical engineering course, with which the students were able to interact remotely to obtain measurement data. The concept of the respective lab was revised with regard to its implementation as a remote laboratory. Fortunately, real-world labs were able to be fully replaced by remote labs. Student perceptions of remote labs were mostly positive. This paper explains the concept and design of the digital twins and the lab as well as the layout, procedure, and finally the results of the accompanying evaluation. However, the implementation of the digital twins to date does not yet include features that address the tactile experience of working in real-world labs.
In the railway technical centers, scheduling the maintenance activities is a very complex task, it consists in ordering, in the time, all the maintenance operations on the workstations, while respecting the number of resources, precedence constraints, and the workstations' availabilities. Currently, this process is not completely automatic. For improving this situation, this paper presents a mathematical model for the maintenance activities scheduling in the case of railway remanufacturing systems. The studied problem is modeled as a flexible job-shop, with the possibility for a job to be executed several times on a stage. MILP formulation is implemented with the Makespan as an objective, representing the time for remanufacturing the train. The aim is to create a generic model for optimizing the planning of the maintenance activities and improving the performance of the railway technical centers. At last, numerical results are presented, discussing the impact of the instances size on the computing time to solve the described problem.
Featherweight Go (FG) is a minimal core calculus that includes essential Go features such as overloaded methods and interface types. The most straightforward semantic description of the dynamic behavior of FG programs is to resolve method calls based on run-time type information. A more efficient approach is to apply a type-directed translation scheme where interface-values are replaced by dictionaries that contain concrete method definitions. Thus, method calls can be resolved by a simple lookup of the method definition in the dictionary. Establishing that the target program obtained via the type-directed translation scheme preserves the semantics of the original FG program is an important task.
To establish this property we employ logical relations that are indexed by types to relate source and target programs. We provide rigorous proofs and give a detailed discussion of the many subtle corners that we have encountered including the need for a step index due to recursive inter- faces and method definitions.
This paper presents a method for supporting the application of Additive Tooling (AT)-based validation environments in integrated product development. Based on a case study, relevant process steps, activities and possible barriers in the realisation of an injection-moulded product are identified and analysed. The aim of the method is to support the target-oriented application of Additive Tooling to obtain physical prototypes at an early stage and to shorten validation cycles.