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Non-responder rate in cardiac resynchronization therapy (CRT) could be partly decreased by individualized parameter optimization excluding adverse hemodynamic timing. In heart failure patients with sinus rhythm, an atrial kick enables the completion of atrial contraction and may significantly enhance the ventricular filling. Compared to that, exclusion of atrial kick is a sign of suboptimal atrioventricular timing. However, the recognition of atrial kick by echocardiography will be negatively affected in patients requiring a very short or long AV delays.
Commercial simulators can only reproduce electrocardiograms (ECG) of the normal and diseased heart rhythm in a simplified waveform and with a low number of channels. With the presented project, the variety of digitally archived ECGs, recorded during electrophysiological examinations, should be made usable as original analogue signals for research and teaching purposes by the development of a special printed circuit board for the mini-computer “Raspberry-Pi “.
Occluders made of the shape memory alloy Nitinol are commonly used to close Atrial Septal Defects (ASD). Until now, standard parameters are missing defining the mechanical properties of these implants. In this study,we developed a special measuring setup for the determination of the mechanical properties of customly available occluders (i.e. Occlutech Figulla®Flex II 29ASD12 and AGA AMPLATZER™9-ASD-012