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Growing demands for cleaner production and higher eco-efficiency in process engineering require a comprehensive analysis of technical and environmental outcomes of customers and society. Moreover, unexpected additional technical or ecological drawbacks may appear as negative side effects of new environ-mentally friendly technologies. The paper conceptualizes a comprehensive ap-proach for analysis and ranking of engineering and ecological requirements in process engineering in order to anticipate secondary problems in eco-design and to avoid compromising the environmental or technological goals. For this purpose, the paper presents a method based on integration of the Quality Func-tion Deployment approach with the Importance-Satisfaction Analysis for the requirements ranking. The proposed method identifies and classifies compre-hensively the potential engineering and eco-engineering contradictions through analysis of correlations within requirements groups such as stakehold-er requirements (SRs) and technical requirements (TRs), and additionally through cross-relationship between SRs and TRs.