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Heart rhythm model and simulation of electrophysiological studies and high-frequency ablations
(2017)
Background: Target of the study was to create an accurate anatomic CAD heart rhythm model, and to show its usefulness for cardiac electrophysiological studies and high-frequency ablations. The method is more careful for the patients’ health and has the potential to replace clinical studies due to its high efficiency regarding time and costs.
Methods: All natural heart components of the new HRM were based on MRI records, which guaranteed electronic functionality. The software CST was used for the construction, while CST’s material library assured genuine tissue properties. It should be applicable to simulate different heart rhythm diseases as well as various diffusions of electromagnetic fields, caused by electrophysiological conduction, inside the heart tissue.
Results: It was achievable to simulate sinus rhythm and fourteen different heart rhythm disturbance with different atrial and ventricular conduction delays. The simulated biological excitation of healthy and sick HRM were plotted by simulated electrodes of four polar right atrial catheter, six polar His bundle catheter, ten polar coronary sinus catheter, four polar ablation catheter and eight polar transesophageal left cardiac catheter. Accordingly, six variables were rebuilt and inserted into the anatomic HRM in order to establish heart catheters for ECG monitoring and HF ablation. The HF ablation catheters made it possible to simulate various types of heart rhythm disturbance ablations with different HF ablation catheters and also showed a functional visualisation of tissue heating. The use of tetrahedral meshing HRM made it attainable to store the results faster accompanied by a higher degree of space saving. The smart meshing function reduced unnecessary high resolutions for coarse structures.
Conclusions: The new HRM for EPS simulation may be additional useful for simulation of heart rhythm disturbance, cardiac pacing, HF ablation and for locating and identification of complex fractioned signals within the atrium during atrial fibrillation HF ablation.
The aim of the smart grid is to achieve more efficient, distributed and secure supply of energy over the traditional power grid by using a bidirectional information flow between the grid agents (e.g. generator node, customer). One of the key optimization problems in smart grid is to produce power among generator nodes with a minimum cost while meeting the customer demand, known as Economic Dispatch Problem (EDP). In recent years, many distributed approaches to solve EDP have been proposed. However, protecting the privacy-sensitive data of individual generator nodes has been largely overlooked in the existing solutions. In this work, we show an attack against an existing auction-based EDP protocol considering a non-colluding semi-honest adversary. We briefly introduce our approach to a practical privacy-preserving EDP solution as our work in progress.
The ability to detect a target signal masked by noise is improved in normal-hearing listeners when interaural phase differences (IPDs) between the ear signals exist either in the masker or in the signal. To improve binaural hearing in bilaterally implanted cochlear implant (BiCI) users, a coding strategy providing the best possible access to IPDs is highly desirable. Outcomes of a previous study (Zirn, Arndt et al. 2016) revealed that a subset of BiCI users showed improved IPD detection thresholds with the fine structure processing strategy FS4 compared to the constant rate strategy HDCIS using narrowband stimuli. In contrast, little differences between the coding strategies were found for broadband stimuli with regard to binaural speech intelligibility level differences (BILD) as an estimate of binaural unmasking. Compared to normalhearing listeners (7.5 ± 1.2 dB) BILD were small in BiCI users (around 0.5 dB with both coding strategies).
In the present work, we investigated the influence of binaural fitting parameters on BILD. In our cohort of BiCI users many were implanted with electrode arrays differing in length left versus right. Because this length difference typically corresponded to the distance of two electrode contacts the first modification of bilateral fitting was a tonotopic adjustment by deactivation of the most apical electrode contact on the side with the deeper inserted array (tonotopic approach).
The second modification was the isolation of the residual, most apical electrode contacts by deactivation of the basally adjacent electrode contact on each side (tonotopic sparse approach). Applying these modifications, BILD improved by up to 1.5 dB.