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Blockchain interoperability: the state of heterogenous blockchain-to-blockchain communication
(2023)
Blockchain technology has been increasingly adopted over the past few years since the introduction of Bitcoin, with several blockchain architectures and solutions being proposed. Most proposed solutions have been developed in isolation, without a standard protocol or cryptographic structure to work with. This has led to the problem of interoperability, where solutions running on different blockchain platforms are unable to communicate, limiting the scope of use. With blockchains being adopted in a variety of fields such as the Internet of Things, it is expected that the problem of interoperability if not addressed quickly, will stifle technology advancement. This paper presents the current state of interoperability solutions proposed for heterogenous blockchain systems. A look is taken at interoperability solutions, not only for cryptocurrencies, but also for general data-based use cases. Current open issues in heterogenous blockchain interoperability are presented. Additionally, some possible research directions are presented to enhance and to extend the existing blockchain interoperability solutions. It was discovered that though there are a number of proposed solutions in literature, few have seen real-world implementation. The lack of blockchain-specific standards has slowed the progress of interoperability. It was also realized that most of the proposed solutions are developed targeting cryptocurrency-based applications.
This paper presents an overview of EREMI, a two-year project funded under ERASMUS+ KA203, and its results. The project team’s main objective was to develop and validate an advanced interdisciplinary higher education curriculum, which includes lifelong learning components. The curriculum focuses on enhancing resource efficiency in the manufacturing industry and optimising poorly or non-digitised industrial physical infrastructure systems. The paper also discusses the results of the project, highlighting the successful achievement of its goals. EREMI effectively supports the transition to Industry 5.0 by preparing a common European pool of future experts. Through comprehensive research and collaboration, the project team has designed a curriculum that equips students with the necessary skills and knowledge to thrive in the evolving manufacturing landscape. Furthermore, the paper explores the significance of EREMI’s contributions to the field, emphasising the importance of resource efficiency and system optimisation in industrial settings. By addressing the challenges posed by under-digitised infrastructure, the project aims to drive sustainable and innovative practices in manufacturing. All five project partner organisations have been actively engaged in offering relevant educational content and framework for decentralised sustainable economic development in regional and national contexts through capacity building at a local level. A crucial element of the added value is the new channel for obtaining feedback from students. The survey results, which are outlined in the paper, offer valuable insights gathered from students, contributing to the continuous improvement of the project.
The article investigates the development of a manufacturing route for highly porous titanium foams suitable for craniofacial surgery applications, particularly in cranioplasties. The study focuses on the polyurethane replication method for foam production and emphasizes reducing residual gas content, as it significantly affects the mechanical properties and suitability for approval of the foams. Various factors such as starting materials, solvent debinding, heating schedules, and hydrogen atmosphere are analyzed for their impact on residual gas content. It is shown that significant reductions in residual gas content can only be achieved by reworking each step of the process. A combination of initial solvent debinding of the PU template with dimethyl sulphoxide, reduction of suspension additives, use of coarser Gd. 1 powders, and an integrated debinding and sintering process under partial hydrogen atmosphere achieves a significant reduction in residual gas content. This way, the potential for producing titanium foams that comply with relevant standards for craniofacial implants is demonstrated.
Lithium-ion batteries exhibit slow voltage dynamics on the minute time scale that are usually associated with transport processes. We present a novel modelling approach toward these dynamics by combining physical and data-driven models into a Grey-box model. We use neural networks, in particular neural ordinary differential equations. The physical structure of the Grey-box model is borrowed from the Fickian diffusion law, where the transport domain is discretized using finite volumes. Within this physical structure, unknown parameters (diffusion coefficient, diffusion length, discretization) and dependencies (state of charge, lithium concentration) are replaced by neural networks and learnable parameters. We perform model-to-model comparisons, using as training data (a) a Fickian diffusion process, (b) a Warburg element, and (c) a resistor-capacitor circuit. Voltage dynamics during constant-current operation and pulse tests as well as electrochemical impedance spectra are simulated. The slow dynamics of all three physical models in the order of ten to 30 min are well captured by the Grey-box model, demonstrating the flexibility of the present approach.
A novel peptidyl-lys metalloendopeptidase (Tc-LysN) from Tramates coccinea was recombinantly expressed in Komagataella phaffii using the native pro-protein sequence. The peptidase was secreted into the culture broth as zymogen (~38 kDa) and mature enzyme (~19.8 kDa) simultaneously. The mature Tc-LysN was purified to homogeneity with a single step anion-exchange chromatography at pH 7.2. N-terminal sequencing using TMTpro Zero and mass spectrometry of the mature Tc-LysN indicated that the pro-peptide was cleaved between the amino acid positions 184 and 185 at the Kex2 cleavage site present in the native pro-protein sequence. The pH optimum of Tc-LysN was determined to be 5.0 while it maintained ≥60% activity between pH values 4.5—7.5 and ≥30% activity between pH values 8.5—10.0, indicating its broad applicability. The temperature maximum of Tc-LysN was determined to be 60 °C. After 18 h of incubation at 80 °C, Tc-LysN still retained ~20% activity. Organic solvents such as methanol and acetonitrile, at concentrations as high as 40% (v/v), were found to enhance Tc-LysN’s activity up to ~100% and ~50%, respectively. Tc-LysN’s thermostability, ability to withstand up to 8 M urea, tolerance to high concentrations of organic solvents, and an acidic pH optimum make it a viable candidate to be employed in proteomics workflows in which alkaline conditions might pose a challenge. The nano-LC-MS/MS analysis revealed bovine serum albumin (BSA)’s sequence coverage of 84% using Tc-LysN which was comparable to the sequence coverage of 90% by trypsin peptides.
In der Geschichte »Die Schule« (Originaltitel: ,,The fun they had“) von 1954 beschreibt der russisch-amerikanische Wissenschaftler und Science fiction Autor Isaac Asimov, wie die Schule der Zukunft im Jahr 2157 aussieht – oder genauer: dass es gar keine Schulen mehr gibt. Jedes Kind hat neben seinem Kinderzimmer im Elternhaus einen kleinen Schulraum, in dem es von einem mechanischen Lehrer (einer Maschine mit Bildschirm und einem Schlitz zum Einwerfen der Hausaufgaben) unterrichtet wird. Diese Lehrmaschine ist perfekt auf die Fähigkeiten des einzelnen Kindes eingestellt und kann es optimal beschulen. Nur: Maschinen können kaputt gehen. Die elfjährige Margie wird von ihrem mechanischen Lehrer wieder und wieder in Geographie abgefragt, aber jedes Mal schlechter benotet. Das sieht die Mutter und ruft den Schulinspektor, um den mechanischen Lehrer zu reparieren.
This article presents the development, parameterization, and experimental validation of a pseudo-three-dimensional (P3D) multiphysics aging model of a 500 mAh high-energy lithium-ion pouch cell with graphite negative electrode and lithium nickel manganese cobalt oxide (NMC) positive electrode. This model includes electrochemical reactions for solid electrolyte interphase (SEI) formation at the graphite negative electrode, lithium plating, and SEI formation on plated lithium. The thermodynamics of the aging reactions are modeled depending on temperature and ion concentration and the reactions kinetics are described with an Arrhenius-type rate law. Good agreement of model predictions with galvanostatic charge/discharge measurements and electrochemical impedance spectroscopy is observed over a wide range of operating conditions. The model allows to quantify capacity loss due to cycling near beginning-of-life as function of operating conditions and the visualization of aging colormaps as function of both temperature and C-rate (0.05 to 2 C charge and discharge, −20 °C to 60 °C). The model predictions are also qualitatively verified through voltage relaxation, cell expansion and cell cycling measurements. Based on this full model, six different aging indicators for determination of the limits of fast charging are derived from post-processing simulations of a reduced, pseudo-two-dimensional isothermal model without aging mechanisms. The most successful aging indicator, compared to results from the full model, is based on combined lithium plating and SEI kinetics calculated from battery states available in the reduced model. This methodology is applicable to standard pseudo-two-dimensional models available today both commercially and as open source.
Design and Implementation of a Camera-Based Tracking System for MAV Using Deep Learning Algorithms
(2023)
In recent years, the advancement of micro-aerial vehicles has been rapid, leading to their widespread utilization across various domains due to their adaptability and efficiency. This research paper focuses on the development of a camera-based tracking system specifically designed for low-cost drones. The primary objective of this study is to build up a system capable of detecting objects and locating them on a map in real time. Detection and positioning are achieved solely through the utilization of the drone’s camera and sensors. To accomplish this goal, several deep learning algorithms are assessed and adopted because of their suitability with the system. Object detection is based upon a single-shot detector architecture chosen for maximum computation speed, and the tracking is based upon the combination of deep neural-network-based features combined with an efficient sorting strategy. Subsequently, the developed system is evaluated using diverse metrics to determine its performance for detection and tracking. To further validate the approach, the system is employed in the real world to show its possible deployment. For this, two distinct scenarios were chosen to adjust the algorithms and system setup: a search and rescue scenario with user interaction and precise geolocalization of missing objects, and a livestock control scenario, showing the capability of surveying individual members and keeping track of number and area. The results demonstrate that the system is capable of operating in real time, and the evaluation verifies that the implemented system enables precise and reliable determination of detected object positions. The ablation studies prove that object identification through small variations in phenotypes is feasible with our approach.
Phytases are widely used food and feed enzymes to improve phosphate availability and reduce anti-nutritional factors. Despite the benefits, enzyme usage is restricted by the harsh conditions in a gastrointestinal tract (pH 2–6) and feed pelleting conditions at high temperatures (60–90 °C). The commercially available phytase Quantum® Blue has been immobilized as CLEAs using glutardialdehyde and soy protein resulting in a residual activity of 33%. The influence of the precipitating agent, precipitant concentration, cross-linker concentration and cross-linking time, sodium borohydride as well as the proteic feeders gluten, soy protein and bovine serum albumin (BSA) has been optimized. The best conditions were 90% (v/v) ethyl lactate as precipitating reagent, 100 mM glutardialdehyde and a soy protein concentration of 227 mg/L with a cross-linking time of 1 h. The intrinsically stable phytase remained its high thermal stability and temperature optimum. The phytase-CLEA achieved a 425% increase of residual activity under harsh acidic conditions between pH 2.2 and 3.5 compared to the free enzyme. The free and immobilized phytase were deployed in an in vitro assay simulating the acidic conditions in the gizzard of poultry at pH 2. The hydrolysis of phytate was monitored using a novel high-performance thin-layer chromatography (HPTLC) analysis and DAD scanner to study the InsPx fingerprint. All lower inositol phosphate pools (InsP1–InsP6) and free phosphate were separated and analyzed. The phytase-CLEA efficiently released 80% of the total phosphate within 180 min, whereas the free enzyme only released 6% in the same time under the same conditions.
In the framework of electro-elasticity theory and the finite element method (FEM), a model is set up for the computation of quantities in surface acoustic wave (SAW) devices accounting for nonlinear effects. These include second-order and third-order intermodulations, second and third harmonic generation and the influence of electro-acoustic nonlinearity on the frequency characteristics of SAW resonators. The model is based on perturbation theory, and requires input material constants, e.g., the elastic moduli up to fourth order for all materials involved. The model is two-dimensional, corresponding to an infinite aperture, but all three Cartesian components of the displacement and electrical fields are accounted for. The first version of the model pertains to an infinite periodic arrangement of electrodes. It is subsequently generalized to systems with a finite number of electrodes. For the latter version, a recursive algorithm is presented which is related to the cascading scheme of Plessky and Koskela and strongly reduces computation time and memory requirements. The model is applied to TC-SAW systems with copper electrodes buried in an oxide film on a LiNbO3 substrate. Results of computations are presented for the electrical current due to third-order intermodulations and the displacement field associated with the second harmonic and second-order intermodulations, generated by monochromatic input tones. The scope of this review is limited to methodological aspects with the goal to enable calculations of nonlinear quantities in SAW devices on inexpensive and easily accessible computing platforms.