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Carbogen inhalation during non-convulsive status epilepticus: A quantitative exploratory analysis of EEG recordings
- Objective: To quantify the effect of inhaled 5% carbon-dioxide/95% oxygen on EEG recordings from patients in non-convulsive status epilepticus (NCSE). Methods: Five children of mixed aetiology in NCSE were given high flow of inhaled carbogen (5% carbon dioxide/95% oxygen) using a face mask for maximum 120s. EEG was recorded concurrently in all patients. The effects of inhaled carbogen onObjective: To quantify the effect of inhaled 5% carbon-dioxide/95% oxygen on EEG recordings from patients in non-convulsive status epilepticus (NCSE). Methods: Five children of mixed aetiology in NCSE were given high flow of inhaled carbogen (5% carbon dioxide/95% oxygen) using a face mask for maximum 120s. EEG was recorded concurrently in all patients. The effects of inhaled carbogen on patient EEG recordings were investigated using band-power, functional connectivity and graph theory measures. Carbogen effect was quantified by measuring effect size (Cohen's d) between "before", "during" and "after" carbogen delivery states. Results: Carbogen's apparent effect on EEG band-power and network metrics across all patients for "before-during" and "before-after" inhalation comparisons was inconsistent across the five patients. Conclusion: The changes in different measures suggest a potentially non-homogeneous effect of carbogen on the patients' EEG. Different aetiology and duration of the inhalation may underlie these non-homogeneous effects. Tuning the carbogen parameters (such as ratio between CO2 and O2, duration of inhalation) on a personalised basis may improve seizure suppression in future.…
Document Type: | Article (reviewed) |
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Zitierlink: | https://opus.hs-offenburg.de/5430 | Bibliografische Angaben |
Title (English): | Carbogen inhalation during non-convulsive status epilepticus: A quantitative exploratory analysis of EEG recordings |
Author: | Sriharsha Ramaraju, Simon ReichertGND, Yujiang Wang, Rob Forsyth, Peter N. Taylor |
Year of Publication: | 2021 |
Creating Corporation: | Public Library of Science |
Page Number: | 14 |
First Page: | 1 |
Last Page: | 14 |
Article Number: | e0240507 |
Parent Title (English): | PLoS One |
Editor: | Andrea Romigi |
Volume: | 16 |
Issue: | 2 |
ISSN: | 1932-6203 (Print) |
ISSN: | 1932-6203 (Online) |
DOI: | https://doi.org/10.1371/journal.pone.0240507 |
Language: | English | Inhaltliche Informationen |
Institutes: | Fakultät Elektrotechnik, Medizintechnik und Informatik (EMI) (ab 04/2019) |
Institutes: | Bibliografie | Formale Angaben |
Open Access: | Open Access |
Licence (German): | Urheberrechtlich geschützt |