Open Access

Steffen Willwacher, Markus Kurz, Johanna Robbin, Matthias Thelen, Joseph Hamill, Luke Kelly, Patrick Mai

• Objective: To identify and evaluate the evidence of the most relevant running-related risk factors (RRRFs) for running-related overuse injuries (ROIs) and to suggest future research directions. Design: Systematic review considering prospective and retrospective studies. (PROSPERO_ID: 236832) Data sources: Pubmed. Connected Papers. The search was performed in February 2021. EligibilityObjective: To identify and evaluate the evidence of the most relevant running-related risk factors (RRRFs) for running-related overuse injuries (ROIs) and to suggest future research directions. Design: Systematic review considering prospective and retrospective studies. (PROSPERO_ID: 236832) Data sources: Pubmed. Connected Papers. The search was performed in February 2021. Eligibility criteria: English language. Studies on participants whose primary sport is running addressing the risk for the seven most common ROIs and at least one kinematic, kinetic (including pressure measurements), or electromyographic RRRF. An RRRF needed to be identified in at least one prospective or two retrospective studies. Results: Sixty-two articles fulfilled our eligibility criteria. Levels of evidence for specific ROIs ranged from conflicting to moderate evidence. Running populations and methods applied varied considerably between studies. While some RRRFs appeared for several ROIs, most RRRFs were specific for a particular ROI. The biomechanical measurements performed in many studies would have allowed for consideration of many more RRRFs than have been reported, highlighting a potential for more effective data usage in the future. Conclusion: This study offers a comprehensive overview of RRRFs for the most common ROIs, which might serve as a starting point to develop ROI-specific risk profiles of individual runners. Future work should use macroscopic (big data) approaches involving long-term data collections in the real world and microscopic approaches involving precise stress calculations using recent developments in biomechanical modelling. However, consensus on data collection standards (including the quantification of workload and stress tolerance variables and the reporting of injuries) is warranted.…