Forensic drug analysis by means of diode-array HPTLC using RF and UV library search
- Diode-array planar chromatography is a versatile tool for identification of pharmaceutical substances In this paper thirty-three compounds with benzodiazepine properties were investigated and the separating conditions for silica gel HPTLC plates and three mobile phases were optimized. Diode-array HPTLC makes it possible to identify all the compounds with high certainty down to a level of 20 ng. AnDiode-array planar chromatography is a versatile tool for identification of pharmaceutical substances In this paper thirty-three compounds with benzodiazepine properties were investigated and the separating conditions for silica gel HPTLC plates and three mobile phases were optimized. Diode-array HPTLC makes it possible to identify all the compounds with high certainty down to a level of 20 ng. An algorithm for spectral recognition which is combined with R F values from the three separation steps into one fit factor is presented. This set of data is unique for each of the compounds investigated and enables unequivocal identification. The method is rapid, inexpensive, and sensitive down to a level of 20 ng mL −1.…
Document Type: | Article (unreviewed) |
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Zitierlink: | https://opus.hs-offenburg.de/853 | Bibliografische Angaben |
Title (English): | Forensic drug analysis by means of diode-array HPTLC using RF and UV library search |
Author: | Bernd SpangenbergStaff MemberORCiDGND, Andrea SeigelStaff Member, Jürgen Kempf, Wolfgang Weinmann |
Year of Publication: | 2005 |
Publisher: | Akadémiai Kiadó |
First Page: | 336 |
Last Page: | 343 |
Parent Title (English): | JPC - Journal of Planar Chromatography - Modern TLC |
Volume: | 18 |
Issue: | 105 |
ISSN: | 0933-4173 (Print) |
ISSN: | 1789-0993 (Online) |
Language: | English | Inhaltliche Informationen |
Institutes: | Fakultät Maschinenbau und Verfahrenstechnik (M+V) |
Institutes: | Bibliografie |
Tag: | Benzodiazepine; Gerichtliche Chemie; Pharmazie | Formale Angaben |
Open Access: | Closed Access |
Licence (German): | Urheberrechtlich geschützt |